Phenotypes associated with this allele

• Allele Symbol: F12^tm1Pbfd
• Allele Name: targeted mutation 1, Peter Burfiend
• Allele ID: MGI:3720935
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	F12^tm1Pbfd/F12^tm1Pbfd	B6.Cg-F12^tm1Pbfd	MGI:3721103
hm2	F12^tm1Pbfd/F12^tm1Pbfd	either: 129X1/SvJ-F12^tm1Pbfd or (involves: 129X1/SvJ * C57BL/6J)	MGI:3721095

Genotype
MGI:3721103

hm1

• Allelic Composition: F12^tm1Pbfd/F12^tm1Pbfd
• Genetic Background: B6.Cg-F12^tm1Pbfd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal response to CNS ischemic injury ( J:123758 )

• following transient cerebral ischemia, fibrin accumulation is less than in wild-type mice

• following transient cerebral ischemia, ischemic neurodegeneration associated with occlusions of vessel lumina is less severe than in wild-type mice and fewer occlusions are detected

decreased cerebral infarct size ( J:123758 )

• following transient cerebral ischemia, infarct size is reduced to less than 50% of that in wild-type mice and results in improved motor coordination and function relative to wild-type mice following injury

homeostasis/metabolism

abnormal response to CNS ischemic injury ( J:123758 )

• following transient cerebral ischemia, fibrin accumulation is less than in wild-type mice

• following transient cerebral ischemia, ischemic neurodegeneration associated with occlusions of vessel lumina is less severe than in wild-type mice and fewer occlusions are detected

decreased cerebral infarct size ( J:123758 )

• following transient cerebral ischemia, infarct size is reduced to less than 50% of that in wild-type mice and results in improved motor coordination and function relative to wild-type mice following injury

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
factor XII deficiency		DOID:2231	OMIM:234000	J:100529

Genotype
MGI:3721095

hm2

• Allelic Composition: F12^tm1Pbfd/F12^tm1Pbfd
• Genetic Background: either: 129X1/SvJ-F12^tm1Pbfd or (involves: 129X1/SvJ * C57BL/6J)

normal phenotype

no abnormal phenotype detected ( J:124154 )

• mice are fertile and viable with no detected abnormalities in the lungs, kidney, liver, small bowel, heart and spleen