Phenotypes associated with this allele

• Allele Symbol: C5ar2^tm1Gdy
• Allele Name: targeted mutation 1, George D Yancopoulos
• Allele ID: MGI:3721065
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	C5ar2^tm1Gdy/C5ar2^tm1Gdy	involves: 129 * C57BL/6	MGI:3722757

Genotype
MGI:3722757

hm1

• Allelic Composition: C5ar2^tm1Gdy/C5ar2^tm1Gdy
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hepatic steatosis in C3^tm1Crr/C3^tm1Crr and C5ar2^tm1Gdy/C5ar2^tm1Gdy mice following partial hepatectomy

behavior/neurological

increased food intake ( J:123294 )

• relative to body weight gain, mutant mice had almost a two-fold increase in cumulative food intake on low-fat diet

adipose tissue

abnormal fat cell morphology ( J:123294 )

• mutant mice on high-fat/high-sucrose diet show adipose tissue composed of significantly small adipocytes

• no significant difference in either total percent body fat or gonadal adipose tissue weight compared to wild-type control

abnormal adipose tissue physiology ( J:123294 )

• total DNA per adipose tissue weight was increased and adipose tissue triglyceride content per unit DNA was significantly reduced in mutant mice on high-fat/high-sucrose diet

• basal triglyceride synthesis was markedly decreased in mutant mice on low-fat diet compared to wild-type control

• adipose tissue from mutant mice had reduction in glycerol release and reduced basal re-esterification

• mutant mice on low-fat diet tended to have delayed triglyceride clearance

homeostasis/metabolism

increased fatty acid oxidation ( J:123294 )

• elevated fatty acid oxidation in heart and skeletal muscle tissue

increased circulating bilirubin level ( J:152533 )

• after 70% partial hepatectomy

increased circulating alanine transaminase level ( J:152533 )

• after 70% partial hepatectomy

abnormal glucose homeostasis ( J:123294 )

• delayed glucose clearance

increased circulating insulin level ( J:123294 )

• plasma insulin level was twofold greater in mutant mice on high-fat/high-sucrose diet

cellular

abnormal cellular respiration ( J:123294 )

• unchanged oxygen consumption levels

• reduced respiratory quotient value

increased fatty acid oxidation ( J:123294 )

• elevated fatty acid oxidation in heart and skeletal muscle tissue

mortality/aging

abnormal induced morbidity/mortality ( J:152533 )

• poor survival (20%) after 70% partial hepatectomy

liver/biliary system

abnormal liver morphology ( J:152533 )

focal hepatic necrosis ( J:152533 )

• after 70% partial hepatectomy

hepatic steatosis ( J:152533 )

• increased steatosis after 70% hepatectomy