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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wt1tm1Nhsn
targeted mutation 1, Naoki Hosen
MGI:3721102
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Wt1tm1Nhsn/Wt1tm1Nhsn involves: 129S2/SvPas * C57BL/6 MGI:3722874
ht2
 		Wt1tm1Nhsn/Wt1+ involves: 129S2/SvPas * C57BL/6 MGI:3722876
cn3
 		Wt1tm1.1Ndha/Wt1tm1Nhsn
Tg(GATA5-cre)1Krc/0 		involves: 129P2/OlaHsd * 129S2/SvPas MGI:4849369


Genotype
MGI:3722874
hm1
Allelic
Composition		 Wt1tm1Nhsn/Wt1tm1Nhsn
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wt1tm1Nhsn mutation (1 available); any Wt1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:123972 )
• heterozygous mating did not produce homozygous mice
• timing of lethality was not determined




Genotype
MGI:3722876
ht2
Allelic
Composition		 Wt1tm1Nhsn/Wt1+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wt1tm1Nhsn mutation (1 available); any Wt1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:123972 )
• heterozygous mice are indistinguishable with respect to hematopoietic cellularity and lineage composition from wild-type littermates
• loss of a single allele did not affect viability and expected Mendelian ratio of heterozygous mice are born by heterozygous crosses
• used for expression study only




Genotype
MGI:4849369
cn3
Allelic
Composition		 Wt1tm1.1Ndha/Wt1tm1Nhsn
Tg(GATA5-cre)1Krc/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(GATA5-cre)1Krc mutation (0 available)
Wt1tm1.1Ndha mutation (0 available); any Wt1 mutation (34 available)
Wt1tm1Nhsn mutation (1 available); any Wt1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:166573 )
• mice die between E16.5 and E18.5 as a result of cardiovascular failure

cardiovascular system
abnormal heart right ventricle morphology ( J:166573 )
• some mice exhibit thinner free walls compared to in wild-type mice
abnormal cardiovascular system physiology ( J:166573 )
• mice die between E16.5 and E18.5 as a result of cardiovascular failure
hemopericardium ( J:166573 )
• mice exhibit pericardial hemorrhaging unlike wild-type mice
poor circulation ( J:166573 )
• at E16.5, mice exhibit an accumulation of blood in the systemic veins unlike in wild-type mice

homeostasis/metabolism
hemopericardium ( J:166573 )
• mice exhibit pericardial hemorrhaging unlike wild-type mice
edema ( J:166573 )
• at E16.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory