Analysis Tools
mortality/aging
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• significantly fewer homozygous mutant animals obtained from heterozygous cross survived to weaning age
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hematopoietic system
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• protection from thrombosis in a pulmonary thromboembolism model in which platelet activation was induced by tail vein infusion of collagen and epinephrin
• the lungs of these mutant mice were largely devoid of platelet thrombi
• profoundly impaired agonist-induced activation of platelet in vitro
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homeostasis/metabolism
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• protection from thrombosis in a pulmonary thromboembolism model in which platelet activation was induced by tail vein infusion of collagen and epinephrin
• the lungs of these mutant mice were largely devoid of platelet thrombi
• profoundly impaired agonist-induced activation of platelet in vitro
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• impaired hemostasis as evidenced by failure to arrest bleeding within 10 minutes following tail resection
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cardiovascular system
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• significant number (19 of 36) of animal showing detectable blood in their stool
• the number is fewer than that of Itgb3tm1Hyn (11 of 11)
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digestive/alimentary system
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• significant number (19 of 36) of animal showing detectable blood in their stool
• the number is fewer than that of Itgb3tm1Hyn (11 of 11)
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