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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Itgb3tm2Mgin
targeted mutation 2, Mark H Ginsberg
MGI:3721109
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Itgb3tm2Mgin/Itgb3tm2Mgin involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N MGI:3722173


Genotype
MGI:3722173
hm1
Allelic
Composition
Itgb3tm2Mgin/Itgb3tm2Mgin
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb3tm2Mgin mutation (0 available); any Itgb3 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• protection from thrombosis in a pulmonary thromboembolism model in which platelet activation was induced by tail vein infusion of collagen and epinephrin
• the lungs of these mutant mice were largely devoid of platelet thrombi
• protection from thrombosis in a model of arterial thrombosis initiated by vascular injury in response to ferric chloride-induced injury of the common carotid artery
• the mutant mice had no occlusion during the 30 minutes following ferric chloride-induced endothelial damage
• profoundly impaired agonist-induced activation of platelet in vitro

homeostasis/metabolism
• protection from thrombosis in a pulmonary thromboembolism model in which platelet activation was induced by tail vein infusion of collagen and epinephrin
• the lungs of these mutant mice were largely devoid of platelet thrombi
• protection from thrombosis in a model of arterial thrombosis initiated by vascular injury in response to ferric chloride-induced injury of the common carotid artery
• the mutant mice had no occlusion during the 30 minutes following ferric chloride-induced endothelial damage
• profoundly impaired agonist-induced activation of platelet in vitro
• there is more than a 3-fold reduction in thrombus volume formed by mutant platelets on a collagen coated surface
• impaired hemostasis as evidenced by failure to arrest bleeding within 10 minutes following tail resection

cardiovascular system
• small number (1 of 23) of animal showing detectable blood in their stool
• the number is fewer than that of Itgb3tm1Hyn (11 of 11) or that of Itgb3tm1Mgin (19 of 36)

digestive/alimentary system
• small number (1 of 23) of animal showing detectable blood in their stool
• the number is fewer than that of Itgb3tm1Hyn (11 of 11) or that of Itgb3tm1Mgin (19 of 36)





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory