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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cyp1atm1Dwn
targeted mutation 1, Daniel W Nebert
MGI:3721229
Summary 2 genotypes


Genotype
MGI:3721552
hm1
Allelic
Composition		 Cyp1atm1Dwn/Cyp1atm1Dwn
Genetic
Background		 B6.129-Cyp1atm1Dwn
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
small thymus ( J:122409 )
• displayed after BaP treatment
decreased leukocyte cell number ( J:122409 )
• displayed after benzo[a]pyrene BaP treatment
small spleen ( J:122409 )
• displayed after BaP treatment

immune system
small thymus ( J:122409 )
• displayed after BaP treatment
decreased leukocyte cell number ( J:122409 )
• displayed after benzo[a]pyrene BaP treatment
small spleen ( J:122409 )
• displayed after BaP treatment

homeostasis/metabolism
increased circulating alanine transaminase level ( J:122409 )
• displayed after BaP treatment
increased circulating aspartate transaminase level ( J:122409 )
• displayed after BaP treatment

endocrine/exocrine glands
small thymus ( J:122409 )
• displayed after BaP treatment




Genotype
MGI:3721555
cx2
Allelic
Composition		 Cyp1atm1Dwn/Cyp1atm1Dwn
Tg(CYP1A1,CYP1A2)1Dwn/Tg(CYP1A1,CYP1A2)1Dwn
Genetic
Background		 B6.Cg-Cyp1atm1Dwn Tg(CYP1A1,CYP1A2)1Dwn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp1atm1Dwn mutation (0 available); any Cyp1a mutation (0 available)
Tg(CYP1A1,CYP1A2)1Dwn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
enlarged liver ( J:122409 )
• after oral treatment with 125 mg/kg/day of benzo[a]pyrene BaP, mice show increased liver size

growth/size/body
enlarged liver ( J:122409 )
• after oral treatment with 125 mg/kg/day of benzo[a]pyrene BaP, mice show increased liver size




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory