All Phenotypes Cd28<tm1Shr> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd28^tm1Shr/Cd28^tm1Shr	involves: 129S4/SvJae * BALB/c * C57BL/6	MGI:3721948
cx2	Cd28^tm1Shr/Cd28^tm1Shr Ctla4^tm1Shr/Ctla4^tm1Shr	C.129S4-Cd28^tm1Shr Ctla4^tm1Shr	MGI:3721947
cx3	Cd28^tm1Shr/Cd28^tm1Shr Ctla4^tm1Shr/Ctla4⁺	C.129S4-Cd28^tm1Shr Ctla4^tm1Shr	MGI:3760760

Allelic Composition	Cd28^tm1Shr/Cd28^tm1Shr
Genetic Background	involves: 129S4/SvJae * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd28^tm1Shr mutation (4 available); any Cd28 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:68642 )

• in vitro T cell proliferation is reduced

decreased CD4-positive, alpha-beta T cell number ( J:68642 )

• the number of CD4+ CD69+ T cells is reduced by 50% compared to in wild-type mice

• however, T and B cell development is normal

decreased interleukin-2 secretion ( J:68642 )

• upon primary stimulation in vitro, IL-2 production is decreased by 50% relative to in wild-type cells

hematopoietic system

decreased T cell proliferation ( J:68642 )

• in vitro T cell proliferation is reduced

decreased CD4-positive, alpha-beta T cell number ( J:68642 )

• the number of CD4+ CD69+ T cells is reduced by 50% compared to in wild-type mice

• however, T and B cell development is normal

cellular

decreased T cell proliferation ( J:68642 )

• in vitro T cell proliferation is reduced

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:68642 )

• in vitro T cell proliferation is reduced relative to wild-type cells

decreased CD4-positive, alpha-beta T cell number ( J:68642 )

• the number of CD4+ CD69+ T cells is reduced by 50% compared to in wild-type mice

• however, T and B cell development is normal

abnormal interferon level ( J:68642 )

• upon secondary stimulation in vitro, interferon-gamma levels are increased relative to in wild-type cells

abnormal interleukin secretion ( J:68642 )

• upon primary stimulation in vitro, IL-2 production is decreased by 50% relative to in wild-type cells

• upon secondary stimulation in vitro, IL-4 and IL-10 production is decreased relative to in wild-type cells

increased length of allograft survival ( J:68642 )

• allograft survival is increased compared to in wild-type mice but mice eventually reject grafts

hematopoietic system

decreased T cell proliferation ( J:68642 )

• in vitro T cell proliferation is reduced relative to wild-type cells

decreased CD4-positive, alpha-beta T cell number ( J:68642 )

• the number of CD4+ CD69+ T cells is reduced by 50% compared to in wild-type mice

• however, T and B cell development is normal

homeostasis/metabolism

abnormal interferon level ( J:68642 )

• upon secondary stimulation in vitro, interferon-gamma levels are increased relative to in wild-type cells

cellular

decreased T cell proliferation ( J:68642 )

• in vitro T cell proliferation is reduced relative to wild-type cells

Allelic Composition	Cd28^tm1Shr/Cd28^tm1Shr Ctla4^tm1Shr/Ctla4⁺
Genetic Background	C.129S4-Cd28^tm1Shr Ctla4^tm1Shr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd28^tm1Shr mutation (4 available); any Cd28 mutation (52 available)
Ctla4^tm1Shr mutation (4 available); any Ctla4 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal CD8-positive, alpha beta T cell morphology ( J:125259 )

• abnormally high levels of CD5 (a marker of T cell activation) and CD8 expression on T cells

immune system

abnormal CD8-positive, alpha beta T cell morphology ( J:125259 )

• abnormally high levels of CD5 (a marker of T cell activation) and CD8 expression on T cells

increased susceptibility to autoimmune disorder ( J:125259 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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