Phenotypes associated with this allele

• Allele Symbol: Tg(Ins2-cre)5Lt
• Allele Name: transgene insertion 5, Edward Leiter
• Allele ID: MGI:3721303
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Ins2-cre)5Lt/Tg(Ins2-cre)5Lt	NOD/ShiLt-Tg(Ins2-cre)5Lt	MGI:3762923
tg2	Tg(Ins2-cre)5Lt/0	NOD/ShiLt-Tg(Ins2-cre)5Lt	MGI:3762924

Genotype
MGI:3762923

tg1

• Allelic Composition: Tg(Ins2-cre)5Lt/Tg(Ins2-cre)5Lt
• Genetic Background: NOD/ShiLt-Tg(Ins2-cre)5Lt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:127015 )

N • homozygotes are viable and live to >40 weeks, as do homozygotes of line 9 (not fully described) in contrast to lethality of homozygosity in lines 3 and 6

immune system

insulitis ( J:127015 )

• widespread insulitis is recorded in many homozygous mice of both sexes at termination of study (40 weeks)

decreased susceptibility to autoimmune disorder ( J:127015 )

• homozygous mice show significant suppression of diabetes (~65% of females and ~85% of males are diabetes free >40 weeks, compared to ~25-30% of hemizygous animals (difference seen in hemizygotes likely due to gene dosage) or hemi- or homozygous mice of transgenic line 9

endocrine/exocrine glands

insulitis ( J:127015 )

• widespread insulitis is recorded in many homozygous mice of both sexes at termination of study (40 weeks)

Genotype
MGI:3762924

tg2

• Allelic Composition: Tg(Ins2-cre)5Lt/0
• Genetic Background: NOD/ShiLt-Tg(Ins2-cre)5Lt

immune system

increased susceptibility to autoimmune diabetes ( J:127015 )

• <15% of male and female hemizygotes are diabetes free by ~32 weeks of age in contrast to homozygotes