Phenotypes associated with this allele

• Allele Symbol: Or10a4^tm5(rtTA)Rax
• Allele Name: targeted mutation 5, Richard Axel
• Allele ID: MGI:3721400
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Or10a4^tm5(rtTA)Rax/Or10a4^+ Tg(tetO-tetX,lacZ)1Gogo/?	involves: 129S1/Sv	MGI:3723463
cx2	Or10a4^tm5(rtTA)Rax/Or10a4^+ Tg(tetO-Kcnj2,lacZ)1Gogo/?	involves: 129S1/Sv * C57BL/6 * CBA	MGI:3723467

Genotype
MGI:3723463

cx1

• Allelic Composition: Or10a4^tm5(rtTA)Rax/Or10a4⁺; Tg(tetO-tetX,lacZ)1Gogo/?
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal olfactory nerve morphology ( J:124299 )

• following doxycycline treatment during gestation or post-weaning, synaptic release in Olfr17+ olfactory sensory neurons is inhibited

• following doxycycline treatment during gestation, targeting of Olfr17+ olfactory nerves fail to converge on the Olfr17+ glomeruli and the number of lacZ+ olfactory nerves decreases with time

• following doxycycline treatment post-weaning, Olfr17+ olfactory nerves migrate randomly within 2 days of induction and their numbers are reduced

Genotype
MGI:3723467

cx2

• Allelic Composition: Or10a4^tm5(rtTA)Rax/Or10a4⁺; Tg(tetO-Kcnj2,lacZ)1Gogo/?
• Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

nervous system

abnormal olfactory nerve morphology ( J:124299 )

• following doxycycline treatment during gestation, Oflr17+ olfactory nerve cells call to enter the olfactory bulb with only a few fibers crossing the cribriform plate that do not converge to form a single glomerulus but innervate a broad region o the ventral portion of the bulb

• following doxycycline treatment during gestation, the number of Oflr17+ olfactory nerves is decreased by 5-fold at P21

• after 40 days of doxycycline, Olfr17+ olfactory nerves no longer converge on a Oflr17+ glomerulus and few nerves stain positive for lacZ