Phenotypes associated with this allele

• Allele Symbol: Omp^tm1(tTA)Gogo
• Allele Name: targeted mutation 1, Joseph Gogos
• Allele ID: MGI:3721403
• Summary: 15 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-tetX,lacZ)1Gogo/?	involves: 129	MGI:3723456
cx2	Or10a4^tm1Mom/Or10a4^+ Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-APPSwInd)Dbo/0	involves: 129 * 129P2/OlaHsd * C3H/HeJ * C57BL/6J	MGI:5811881
cx3	Omp^tm1(tTA)Gogo/Omp^tm2(spH)Mom Tg(tetO-APPSwInd)Dbo/0	involves: 129 * 129P2/OlaHsd * C3H/HeJ * C57BL/6J	MGI:5811877
cx4	Or8a1^tm25Mom/Or8a1^+ Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-APPSwInd)Dbo/0	involves: 129 * C3H/HeJ * C57BL/6J	MGI:5811882
cx5	Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-APPSwInd)Dbo/0	involves: 129 * C3H/HeJ * C57BL/6J	MGI:5811870
cx6	Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-Kcnj2,lacZ)1Gogo/?	involves: 129 * C57BL/6 * CBA	MGI:3723464
cx7	Or4e5^tm2Rax/Or4e5^+ Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-Kcnj2,lacZ)1Gogo/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3723466
cx8	Or10a4^tm6Rax/Or10a4^tm6Rax Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-Kcnj2,lacZ)1Gogo/?	involves: 129S1/Sv * C57BL/6 * CBA	MGI:3723465
cx9	Ngfr^tm1Jae/Ngfr^+ Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S4/SvJae * C57BL/6	MGI:3723452
cx10	Ngfr^tm1Jae/Ngfr^tm1Jae Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S4/SvJae * C57BL/6	MGI:3723445
cx11	Bdnf^tm1Jae/Bdnf^+ Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S4/SvJae * C57BL/6	MGI:3723444
cx12	Ngfr^tm1Jae/Ngfr^tm1Jae Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-tetX,lacZ)1Gogo/?	involves: 129S4/SvJae * C57BL/6	MGI:3723454
cx13	Bdnf^tm2(BDNF)Gogo/Bdnf^+ Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S/SvEv	MGI:3723439
cx14	Bdnf^tm1(BDNF)Gogo/Bdnf^+ Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S/SvEv	MGI:3723437
cx15	Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-tetX,lacZ)2Gogo/?	Not Specified	MGI:3723455

Genotype
MGI:3723456

cx1

• Allelic Composition: Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-tetX,lacZ)1Gogo/?
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal olfactory nerve morphology ( J:124050 , J:124299 )

• following doxycycline treatment, synaptic release in olfactory sensory neurons is inhibited (J:124050)

• following doxycycline treatment, the number of terminal branches of olfactory nerves is modestly increased relative to in wild-type mice (J:124050)

• following doxycycline treatment, synaptic release in olfactory sensory neurons is inhibited (J:124299)

Genotype
MGI:5811881

cx2

• Allelic Composition: Or10a4^tm1Mom/Or10a4⁺; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-APPSwInd)Dbo/0
• Genetic Background: involves: 129 * 129P2/OlaHsd * C3H/HeJ * C57BL/6J

craniofacial

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

growth/size/body

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

nervous system

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

abnormal olfactory bulb layer morphology ( J:199798 )

• no obvious Olfr17+ axonal convergence is seen in the olfactory bulb

respiratory system

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

taste/olfaction

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

Genotype
MGI:5811877

cx3

• Allelic Composition: Omp^tm1(tTA)Gogo/Omp^tm2(spH)Mom; Tg(tetO-APPSwInd)Dbo/0
• Genetic Background: involves: 129 * 129P2/OlaHsd * C3H/HeJ * C57BL/6J

taste/olfaction

impaired olfaction ( J:199798 )

• mice show virtually no detectable focal signals when presented with the an array of odors, suggesting loss of olfactory function

• administration of doxycycline from 3 to 4 weeks of age, results in modest odor-induced SpH-signals, while administration for 3 weeks, further restores odor-induced signals, with more glomeruli activated by odors

Genotype
MGI:5811882

cx4

• Allelic Composition: Or8a1^tm25Mom/Or8a1⁺; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-APPSwInd)Dbo/0
• Genetic Background: involves: 129 * C3H/HeJ * C57BL/6J

craniofacial

decreased olfactory sensory neuron number ( J:199798 )

• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number

• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

growth/size/body

decreased olfactory sensory neuron number ( J:199798 )

• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number

• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

nervous system

decreased olfactory sensory neuron number ( J:199798 )

• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number

• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

respiratory system

decreased olfactory sensory neuron number ( J:199798 )

• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number

• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

taste/olfaction

decreased olfactory sensory neuron number ( J:199798 )

• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number

• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

Genotype
MGI:5811870

cx5

• Allelic Composition: Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-APPSwInd)Dbo/0
• Genetic Background: involves: 129 * C3H/HeJ * C57BL/6J

craniofacial

abnormal olfactory epithelium morphology ( J:176127 )

• olfactory epithelium is thinner in 3 week old mice

• olfactory epithelium shows fewer dendritic knobs with fewer cilia

abnormal olfactory sensory neuron morphology ( J:199798 )

• axonal degeneration of olfactory sensory neurons

• treatment with doxycycline prevents axonal degeneration

decreased olfactory sensory neuron number ( J:176127 )

• mature olfactory sensory neuron population is reduced in 3 week old mice

• however, the immature sensory neuron population is normal

growth/size/body

abnormal olfactory epithelium morphology ( J:176127 )

• olfactory epithelium is thinner in 3 week old mice

• olfactory epithelium shows fewer dendritic knobs with fewer cilia

abnormal olfactory sensory neuron morphology ( J:199798 )

• axonal degeneration of olfactory sensory neurons

• treatment with doxycycline prevents axonal degeneration

decreased olfactory sensory neuron number ( J:176127 )

• mature olfactory sensory neuron population is reduced in 3 week old mice

• however, the immature sensory neuron population is normal

nervous system

abnormal olfactory sensory neuron morphology ( J:199798 )

• axonal degeneration of olfactory sensory neurons

• treatment with doxycycline prevents axonal degeneration

decreased olfactory sensory neuron number ( J:176127 )

• mature olfactory sensory neuron population is reduced in 3 week old mice

• however, the immature sensory neuron population is normal

abnormal olfactory bulb morphology ( J:199798 )

• structure of the olfactory bulb is altered

abnormal olfactory bulb glomerular layer morphology ( J:199798 )

• the glomerular layer is thinner, with a massive loss of glomeruli

• treatment with doxycycline restores the glomerular layer, although the glomerular layer appears disorganized

abnormal olfactory bulb outer nerve layer morphology ( J:199798 )

• outer nerve layer is thinner

• increase in apoptosis in the outer nerve layer

• treatment with doxycycline restores the outer nerve layer

small olfactory bulb ( J:199798 )

• reduction in size of the olfactory bulb

abnormal synaptic bouton morphology ( J:199798 )

• mice show a reduction in VGlu2 staining, indicating loss of olfactory sensory neuron axon terminals in the olfactory bulb

• treatment with doxycycline restores these axon terminals in the olfactory bulb

neurodegeneration ( J:176127 )

• treatment with doxycycline reverses neurodegeneration

• neurodegeneration of olfactory sensory neurons, with most lost between 7 and 14 days of age

abnormal olfactory sensory neuron physiology ( J:176127 )

• rapid and widespread apoptosis in mature olfactory sensory neurons

respiratory system

abnormal olfactory epithelium morphology ( J:176127 )

• olfactory epithelium is thinner in 3 week old mice

• olfactory epithelium shows fewer dendritic knobs with fewer cilia

abnormal olfactory sensory neuron morphology ( J:199798 )

• axonal degeneration of olfactory sensory neurons

• treatment with doxycycline prevents axonal degeneration

decreased olfactory sensory neuron number ( J:176127 )

• mature olfactory sensory neuron population is reduced in 3 week old mice

• however, the immature sensory neuron population is normal

abnormal olfactory sensory neuron physiology ( J:176127 )

• rapid and widespread apoptosis in mature olfactory sensory neurons

taste/olfaction

abnormal olfactory epithelium morphology ( J:176127 )

• olfactory epithelium is thinner in 3 week old mice

• olfactory epithelium shows fewer dendritic knobs with fewer cilia

abnormal olfactory sensory neuron morphology ( J:199798 )

• axonal degeneration of olfactory sensory neurons

• treatment with doxycycline prevents axonal degeneration

decreased olfactory sensory neuron number ( J:176127 )

• mature olfactory sensory neuron population is reduced in 3 week old mice

• however, the immature sensory neuron population is normal

abnormal olfactory sensory neuron physiology ( J:176127 )

• rapid and widespread apoptosis in mature olfactory sensory neurons

impaired olfaction ( J:199798 )

• in a buried food assay, mice take a longer time to find the cookie

• in an avoidance assay in which the simple odorant isovaleric acid is added to drinking water and becomes an aversive stimulus associated with an LiCl injection, the conditioned mutants show a higher preference for the odor-water than controls, indicating decreased ability to detect the odor

• administration of doxycycline restores odor detection in both the buried food assay and at high concentration of isovaleric acid in the avoidance assay

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:199798

Genotype
MGI:3723464

cx6

• Allelic Composition: Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-Kcnj2,lacZ)1Gogo/?
• Genetic Background: involves: 129 * C57BL/6 * CBA

nervous system

abnormal olfactory bulb morphology ( J:124299 )

• following doxycycline treatment, organization of the glomeruli in the dorsal part of the bulb remains disorganized, thinly innervated, necklace glomeruli are absent, and nerves that enter the bulb coalesce into a giant glomerulus-like structure

abnormal olfactory nerve morphology ( J:124299 )

• following doxycycline treatment, the spiking activity of olfactory nerves is inhibited

• following doxycycline treatment, the entry of the sensory neuron into the olfactory bulb is delayed

Genotype
MGI:3723466

cx7

• Allelic Composition: Or4e5^tm2Rax/Or4e5⁺; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-Kcnj2,lacZ)1Gogo/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

nervous system

abnormal olfactory nerve morphology ( J:124299 )

• following doxycycline treatment, at P1 and more profoundly at P21 Olfr17+ olfactory nerves are diffusely distributed and 75% of those that enter the olfactory bulb innervate two to three glomeruli in the ventral portion of the bulb

Genotype
MGI:3723465

cx8

• Allelic Composition: Or10a4^tm6Rax/Or10a4^tm6Rax; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-Kcnj2,lacZ)1Gogo/?
• Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

nervous system

abnormal olfactory nerve morphology ( J:124299 )

• following doxycycline treatment, at P1 and more profoundly at P21 Olfr17+ olfactory nerves are diffusely distributed and those that enter the olfactory bulb sparsely innervate an average of 16 glomeruli in the ventral portion of the bulb

Genotype
MGI:3723452

cx9

• Allelic Composition: Ngfr^tm1Jae/Ngfr⁺; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-tetX,lacZ)2Gogo/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6

nervous system

abnormal olfactory nerve morphology ( J:124050 )

• following doxycycline treatment, terminal-arbor complexity is partially rescued (4 branches per axon compared to 1.96+/-0.17 in Tg(tetO-tetX,lacZ)2Gogo Omp^tm1(tTA)Gogo mice and 6.6+/-0.19 in wild-type mice)

Genotype
MGI:3723445

cx10

• Allelic Composition: Ngfr^tm1Jae/Ngfr^tm1Jae; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-tetX,lacZ)2Gogo/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6

nervous system

abnormal olfactory nerve morphology ( J:124050 )

• following doxycycline treatment, terminal-arbor complexity of olfactory nerves is rescued with 7 branches per axon compared to 1.96+/-0.17 in Tg(tetO-tetX,lacZ)2Gogo Omp^tm1(tTA)Gogo mice and 6.6+/-0.19 in wild-type mice but branching length is not restored

Genotype
MGI:3723444

cx11

• Allelic Composition: Bdnf^tm1Jae/Bdnf⁺; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-tetX,lacZ)2Gogo/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6

nervous system

nervous system phenotype ( J:124050 )

N • following doxycycline treatment, terminal-arbor complexity of olfactory nerves is normal

Genotype
MGI:3723454

cx12

• Allelic Composition: Ngfr^tm1Jae/Ngfr^tm1Jae; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-tetX,lacZ)1Gogo/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6

nervous system

abnormal olfactory nerve morphology ( J:124050 )

• the positive effect of global presynaptic inactinity on the total branch length is somewhat attenuated

Genotype
MGI:3723439

cx13

• Allelic Composition: Bdnf^{tm2(BDNF)Gogo}/Bdnf⁺; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-tetX,lacZ)2Gogo/?
• Genetic Background: involves: 129S/SvEv

nervous system

abnormal olfactory nerve morphology ( J:124050 )

• following doxycycline treatment, terminal-arbor complexity at P6 is reduced similar to in Tg(tetO-tetX,lacZ)2Gogo Omp^tm1(tTA)Gogo mice

Genotype
MGI:3723437

cx14

• Allelic Composition: Bdnf^{tm1(BDNF)Gogo}/Bdnf⁺; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-tetX,lacZ)2Gogo/?
• Genetic Background: involves: 129S/SvEv

nervous system

nervous system phenotype ( J:124050 )

N • following doxycycline treatment, terminal-arbor complexity and total length of olfactory nerve axons is normal

Genotype
MGI:3723455

cx15

• Allelic Composition: Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-tetX,lacZ)2Gogo/?
• Genetic Background: Not Specified

nervous system

abnormal olfactory nerve morphology ( J:124050 )

• following doxycycline treatment, synaptic release in olfactory sensory neurons is inhibited

• following doxycycline treatment, P6 mice exhibit a reduction in terminal-arbor complexity (1.96+/-0.17 branches per axon arbor compared to 6.6+/-0.19 in wild-type mice) and total length (153.29+/-13.16 um compared to 231.6+/-0.19 um in wild-type mice)

• following doxycycline treatment, large axonal varicosities are increased as are signs of degeneration

• however, normal branching can be reconstituted with the application of an NMDR inhibitor (MK-801)