Analysis Tools|
Allele Symbol Allele Name Allele ID |
Shbtm1.1Miwe targeted mutation 1.1, Michael Welsh MGI:3721903 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected embryos are born
• however, mice that are born are viable, fertile and show no obvious defects
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• mice produced from null parents exhibit severe malformations including resorptions or loss of embryo structures and mild malformations including tail rotation defects, neural tube closure defects or superficial hemorrhaging
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• some mice have an open neural tube
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• some mice exhibit external hemorrhaging
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• some mice have tail defects such as a twisted tail
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• some mice have an open neural tube
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• authors state that the defects similar to those seen in homozygous mice are present in heterozygotes when one parent is homozygous and the other heterozygous for the null allele
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• maternal inheritance of the null allele is increased
• at E10.5, mice carrying a maternal copy of the null allele were more common than those carrying a maternal wild-type copy
• transmission rations of wild-type to null allele are 31% to 54% at E10.5 and 19% to 81% during ovulation
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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