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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CMV-IghvaD11)DCat
transgene insertion D, Antonio Cattaneo
MGI:3721909
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(CMV-IghvaD11)DCat/0
Tg(CMV-IgkvaD11)BCat/0
involves: C57BL/6 * SJL MGI:3721933
cx2
Tg(CMV-IghvaD11)DCat/0
Tg(CMV-IgkvaD11)ACat/0
involves: C57BL/6 * SJL MGI:3721938


Genotype
MGI:3721933
cx1
Allelic
Composition
Tg(CMV-IghvaD11)DCat/0
Tg(CMV-IgkvaD11)BCat/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3721938
cx2
Allelic
Composition
Tg(CMV-IghvaD11)DCat/0
Tg(CMV-IgkvaD11)ACat/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype

Dilation of lateral ventricles and cholinergic deficit in aged Tg(CMV-IghvaD11)DCat/0 Tg(CMV-IgkvaD11)ACat/0 mice

behavior/neurological
• aged mice show an impairment in an object recognition test (J:62713)
• 6 month old mice do not preferentially explore the new object during an object recognition test, spending an equal time exploring the new and the old object (J:212312)
• when given a new learning test following the retention test, mice show a deficit in transfer of learning capacity to a new situation compared to controls
• although mice initially show normal learning curves in the radial maze of spatial learning, when tested at day 44, mice make significantly more errors than at day 14, and in a subsequent transfer test in which mice are exposed to a different disposition of the baits, mice show a decrease in ability to transfer their learning capacity to a new situation
• when retested 31 days after initial training period, mice do not retain level of performance initial acquired with learning
• in a radial maze test, mice show working memory errors
• mice show marked impairment in coordination and fatigability assessed by the rotarod test
• adult mice show abnormal hind limb position when walking or suspended by tail
• adults display waddling gait due to abnormal hind limb position; mice walk on tiptoes of hind feet
• adult transgenic mice show increased latency in hot plate test

growth/size/body
• mice appear normal but body weight is slightly decreased by 25% compared to littermates

hematopoietic system
• transgenic mice have 3-fold more apoptotic cells in the spleen compared to controls
• in adults, number of viable splenocytes in transgenic spleens is dramatically lower than in controls; proportion of IgG-positive cells is reduced while IgD-positive cells are slightly increased

immune system
• transgenic mice have 3-fold more apoptotic cells in the spleen compared to controls
• in adults, number of viable splenocytes in transgenic spleens is dramatically lower than in controls; proportion of IgG-positive cells is reduced while IgD-positive cells are slightly increased

muscle
• fibers show an irregular shape
• fibers show a decreased cross-sectional area
• at 2 months, significant reduction of the mass (atrophy) of longitudinal dorsal muscles and the flexor and abducent muscles of the hind limbs is observed in adults, but not in mice 2-30 days postnatal

nervous system
• majority of neurons in lumbar DRG have pyknotic nuclei
• amyloid plaques are seen in the cortex, the neostriatum, the hippocampus, and other areas of the brain of aged mice (J:62713)
• plaques occupy a significant portion of the entorhinal cortex, with an amyloid burden equal to 21% of the total surface (J:62713)
• innervating fibers in the spleen are scattered throughout germinal center and marginal zone, without reaching the central artery
• cells are greatly reduced in size (157-193 um2 vs 218-311 um2 in controls) at 2 months
• markedly smaller at 2 months of age compared to controls (J:79946)
• size of the superior cervical ganglion is decreased due to extensive shrinkage of cell body (J:212312)
• free nerve growth factor in the brain of aged mice is at least 50% lower than in controls
• dilation of the lateral ventricles in aged (15-18 months) mice
• extent of CA3 mossy fibers is markedly reduced at 2 months
• atrophy of the hippocampus
• surface of the hippocampus is decreased
• atrophy of the cerebral cortex, with a 34% reduction in the number of neurons in the frontal cortex
• DNA fragmentation, indicative of apoptosis, is seen in the cortex of aged mice
• cortical thickness is reduced in frontal areas of aged mice
• neurofibrillary tangles in cortical and hippocampal neurons of aged mice
• aged mice show insoluble and hyperphosphorylated tau in neuronal and glial cells in the cortex and hippocampus (J:62713)
• phosphorylated-tau immunoreactivity is mainly located in the neuronal cell bodies or in apical dendrites (J:212312)
• total number of basal forebrain cholinergic neurons in aged mice shows an overall reduction of 60% and a 93% decrease in the medial septum (J:62713)
• number of choline acetyl transferase ChAT neurons in basal forebrain and hippocampus is reduced in adult animals relative to controls (J:79946)
• cell bodies of ChAT-positive fibers projecting to cortex and hippocampus show marked shrinkage (J:79946)
• decrease in the number of ChAT-positive cholinergic neurons in the medial septum and diagonal band of Broca as early as 2 months of age (J:212312)
• dystrophic neurites in the cortex of aged mice
• neuron size with respect to cell body size is dramatically reduced with median size of 425 um2 in controls vs 75 um2 in transgenic mice at 2 months
• progressive neurodegeneration

skeleton
• mice often develop scoliosis of the back

cellular
• majority of neurons in lumbar DRG have pyknotic nuclei
• transgenic mice have 3-fold more apoptotic cells in the spleen compared to controls

homeostasis/metabolism
• amyloid deposits are seen in sarcoplasm of skeletal muscle
• amyloid plaques are seen in the cortex, the neostriatum, the hippocampus, and other areas of the brain of aged mice (J:62713)
• plaques occupy a significant portion of the entorhinal cortex, with an amyloid burden equal to 21% of the total surface (J:62713)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:62713





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory