Allele Symbol Allele Name Allele ID |
Tg(CMV-IghvaD11)DCat transgene insertion D, Antonio Cattaneo MGI:3721909 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
Dilation of lateral ventricles and cholinergic deficit in aged Tg(CMV-IghvaD11)DCat/0 Tg(CMV-IgkvaD11)ACat/0 mice
• aged mice show an impairment in an object recognition test
(J:62713)
• 6 month old mice do not preferentially explore the new object during an object recognition test, spending an equal time exploring the new and the old object
(J:212312)
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• when given a new learning test following the retention test, mice show a deficit in transfer of learning capacity to a new situation compared to controls
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• although mice initially show normal learning curves in the radial maze of spatial learning, when tested at day 44, mice make significantly more errors than at day 14, and in a subsequent transfer test in which mice are exposed to a different disposition of the baits, mice show a decrease in ability to transfer their learning capacity to a new situation
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• when retested 31 days after initial training period, mice do not retain level of performance initial acquired with learning
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• in a radial maze test, mice show working memory errors
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• mice show marked impairment in coordination and fatigability assessed by the rotarod test
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• adult mice show abnormal hind limb position when walking or suspended by tail
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• adults display waddling gait due to abnormal hind limb position; mice walk on tiptoes of hind feet
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• adult transgenic mice show increased latency in hot plate test
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• mice appear normal but body weight is slightly decreased by 25% compared to littermates
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• transgenic mice have 3-fold more apoptotic cells in the spleen compared to controls
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• in adults, number of viable splenocytes in transgenic spleens is dramatically lower than in controls; proportion of IgG-positive cells is reduced while IgD-positive cells are slightly increased
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• transgenic mice have 3-fold more apoptotic cells in the spleen compared to controls
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• in adults, number of viable splenocytes in transgenic spleens is dramatically lower than in controls; proportion of IgG-positive cells is reduced while IgD-positive cells are slightly increased
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• fibers show an irregular shape
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• fibers show a decreased cross-sectional area
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• at 2 months, significant reduction of the mass (atrophy) of longitudinal dorsal muscles and the flexor and abducent muscles of the hind limbs is observed in adults, but not in mice 2-30 days postnatal
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• majority of neurons in lumbar DRG have pyknotic nuclei
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• amyloid plaques are seen in the cortex, the neostriatum, the hippocampus, and other areas of the brain of aged mice
(J:62713)
• plaques occupy a significant portion of the entorhinal cortex, with an amyloid burden equal to 21% of the total surface
(J:62713)
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• innervating fibers in the spleen are scattered throughout germinal center and marginal zone, without reaching the central artery
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• cells are greatly reduced in size (157-193 um2 vs 218-311 um2 in controls) at 2 months
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• markedly smaller at 2 months of age compared to controls
(J:79946)
• size of the superior cervical ganglion is decreased due to extensive shrinkage of cell body
(J:212312)
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• free nerve growth factor in the brain of aged mice is at least 50% lower than in controls
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• dilation of the lateral ventricles in aged (15-18 months) mice
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• extent of CA3 mossy fibers is markedly reduced at 2 months
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• atrophy of the hippocampus
• surface of the hippocampus is decreased
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• atrophy of the cerebral cortex, with a 34% reduction in the number of neurons in the frontal cortex
• DNA fragmentation, indicative of apoptosis, is seen in the cortex of aged mice
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• cortical thickness is reduced in frontal areas of aged mice
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• neurofibrillary tangles in cortical and hippocampal neurons of aged mice
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• aged mice show insoluble and hyperphosphorylated tau in neuronal and glial cells in the cortex and hippocampus
(J:62713)
• phosphorylated-tau immunoreactivity is mainly located in the neuronal cell bodies or in apical dendrites
(J:212312)
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• total number of basal forebrain cholinergic neurons in aged mice shows an overall reduction of 60% and a 93% decrease in the medial septum
(J:62713)
• number of choline acetyl transferase ChAT neurons in basal forebrain and hippocampus is reduced in adult animals relative to controls
(J:79946)
• cell bodies of ChAT-positive fibers projecting to cortex and hippocampus show marked shrinkage
(J:79946)
• decrease in the number of ChAT-positive cholinergic neurons in the medial septum and diagonal band of Broca as early as 2 months of age
(J:212312)
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• dystrophic neurites in the cortex of aged mice
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• neuron size with respect to cell body size is dramatically reduced with median size of 425 um2 in controls vs 75 um2 in transgenic mice at 2 months
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• progressive neurodegeneration
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• majority of neurons in lumbar DRG have pyknotic nuclei
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• transgenic mice have 3-fold more apoptotic cells in the spleen compared to controls
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• amyloid deposits are seen in sarcoplasm of skeletal muscle
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• amyloid plaques are seen in the cortex, the neostriatum, the hippocampus, and other areas of the brain of aged mice
(J:62713)
• plaques occupy a significant portion of the entorhinal cortex, with an amyloid burden equal to 21% of the total surface
(J:62713)
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Alzheimer's disease | DOID:10652 | J:62713 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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