All Phenotypes Tg(CMV-IgkvaD11)BCat MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Sorl1^tm1Tew/Sorl1^tm1Tew Tg(CMV-IgkvaD11)BCat/Tg(CMV-IgkvaD11)BCat	involves: 129 * C57BL/6 * SJL	MGI:5581430
cx2	Tg(CMV-IghvaD11)DCat/0 Tg(CMV-IgkvaD11)BCat/0	involves: C57BL/6 * SJL	MGI:3721933
cx3	Tg(CMV-IghvaD11)CCat/Tg(CMV-IghvaD11)CCat Tg(CMV-IgkvaD11)BCat/0	involves: C57BL/6 * SJL	MGI:3721934
cx4	Tg(CMV-IghvaD11)CCat/0 Tg(CMV-IgkvaD11)ACat/0 Tg(CMV-IgkvaD11)BCat/0	involves: C57BL/6 * SJL	MGI:3721935
cx5	Tg(CMV-IghvaD11)CCat/0 Tg(CMV-IgkvaD11)BCat/0	involves: C57BL/6 * SJL	MGI:3721936
tg6	Tg(CMV-IgkvaD11)BCat/Tg(CMV-IgkvaD11)BCat	involves: 129 * C57BL/6 * SJL	MGI:5581429
tg7	Tg(CMV-IgkvaD11)BCat/Tg(CMV-IgkvaD11)BCat	involves: C57BL/6 * SJL	MGI:5578629

Allelic Composition	Sorl1^tm1Tew/Sorl1^tm1Tew Tg(CMV-IgkvaD11)BCat/Tg(CMV-IgkvaD11)BCat
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sorl1^tm1Tew mutation (0 available); any Sorl1 mutation (132 available)
Tg(CMV-IgkvaD11)BCat mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal object recognition memory ( J:210074 )

• at 3 and 6 months of age, mice do not distinguish between old and new objects in the object recognition test

• at 12-14 months of age, however, the non-spatial memory deficit seen in the object recognition test disappears

impaired spatial learning ( J:210074 )

• during the acquisition phase of the Morris water maze, 12 month old mutants do not learn as well as wild-type mice

• during the probe phase of the Morris water maze, 3, 6, and 12-14 month old mice are unable to remember the target quadrant

homeostasis/metabolism

amyloid beta deposits ( J:210074 )

• amyloid beta immunoreactive clusters in dystrophic neurites are seen to a similar extent in the hippocampus as in single Tg(CMV-IgkvaD11)BCat mice at 3 months of age, however by 6 months, the number of amyloid beta immunoreactive clusters is increased two-fold, but then is similar to single transgenics at 12-14 months of age, indicating acceleration of the amyloidogenic process

nervous system

amyloid beta deposits ( J:210074 )

tau protein deposits ( J:210074 )

• phosphorylated tau is seen in neurons of the lateral entorhinal cortex, the neocortex and the hippocampus at 12-14 months of age, but not at earlier times; somatodendritic localization of phosphorylated tau is not observed

abnormal cholinergic neuron morphology ( J:210074 )

• mice show decreased numbers of ChAT-positive neurons only in the medial septum/diagonal band of Broca at 12-14 months of age

• normal numbers of ChAT-positive neurons are seen in the nucleus basalis of Meynert at 3, 6, and 12-14 months of age and in the medial septum/diagonal band of Broca at 3, and 6 months of age, indicating some protection from cholinergic neurodegeneration at early stages

Allelic Composition	Tg(CMV-IghvaD11)DCat/0 Tg(CMV-IgkvaD11)BCat/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:79946 )

• no viable offspring

Allelic Composition	Tg(CMV-IghvaD11)CCat/Tg(CMV-IghvaD11)CCat Tg(CMV-IgkvaD11)BCat/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:79946 )

• all mice die before 20 days postnatal; most die within 1 week

growth/size/body

decreased body weight ( J:79946 )

• mice do not gain weight after birth; mice surviving ~3 weeks show decreased body weight relative to littermates

vision/eye

delayed eyelid opening ( J:79946 )

integument

delayed hair appearance ( J:79946 )

• delay in hair growth is observed

Allelic Composition	Tg(CMV-IghvaD11)CCat/0 Tg(CMV-IgkvaD11)ACat/0 Tg(CMV-IgkvaD11)BCat/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:79946 )

• only 50% of mice survive to adulthood

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:79946 )

• mice appear normal but body weight is slightly decreased by 25% compared to littermates

behavior/neurological

abnormal spatial learning ( J:79946 )

• when given a new learning test following the retention test, mice show a deficit in transfer of learning capacity to a new situation compared to controls

abnormal long-term spatial reference memory ( J:79946 )

• when retested 31 days after initial training period, mice do not retain level of performance initial acquired with learning

abnormal spatial working memory ( J:79946 )

• in a radial maze test, mice show working memory errors

impaired coordination ( J:79946 )

• mice show marked impairment in coordination and fatigability assessed by the rotarod test

abnormal limb posture ( J:79946 )

• adult mice show abnormal hind limb position when walking or suspended by tail

abnormal gait ( J:79946 )

• adults display waddling gait due to abnormal hind limb position; mice walk on tiptoes of hind feet

increased thermal nociceptive threshold ( J:79946 )

• adult transgenic mice show increased latency in hot plate test

nervous system

increased neuron apoptosis ( J:79946 )

• majority of neurons in lumbar DRG have pyknotic nuclei

abnormal sympathetic system morphology ( J:79946 )

• innervating fibers in the spleen are scattered throughout germinal center and marginal zone, without reaching the central artery

abnormal superior cervical ganglion morphology ( J:79946 )

• cells are greatly reduced in size (157-193 um² vs 218-311 um² in controls) at 2 months

small superior cervical ganglion ( J:79946 )

• markedly smaller at 2 months of age compared to controls

abnormal hippocampal mossy fiber morphology ( J:79946 )

• extent of CA3 mossy fibers is markedly reduced at 2 months

abnormal cholinergic neuron morphology ( J:79946 )

• number of choline acetyl transferase ChAT neurons in basal forebrain and hippocampus is reduced in adult animals relative to controls

• cell bodies of ChAT-positive fibers projecting to cortex and hippocampus show marked shrinkage

abnormal lumbar dorsal root ganglion morphology ( J:79946 )

• neuron size with respect to cell body size is dramatically reduced with median size of 425 um² in controls vs 75 um² in transgenic mice at 2 months

muscle

abnormal skeletal muscle fiber morphology ( J:79946 )

• fibers show an irregular shape

decreased skeletal muscle fiber diameter ( J:79946 )

• fibers show a decreased cross-sectional area

decreased skeletal muscle mass ( J:79946 )

• at 2 months, significant reduction of the mass (atrophy) of longitudinal dorsal muscles and the flexor and abducent muscles of the hind limbs is observed in adults, but not in mice 2-30 days postnatal

hematopoietic system

increased splenocyte apoptosis ( J:79946 )

• transgenic mice have 3-fold more apoptotic cells in the spleen compared to controls

abnormal splenic cell ratio ( J:79946 )

• in adults, number of viable splenocytes in transgenic spleens is dramatically lower than in controls; proportion of IgG-positive cells is reduced while IgD-positive cells are slightly increased

immune system

increased splenocyte apoptosis ( J:79946 )

• transgenic mice have 3-fold more apoptotic cells in the spleen compared to controls

abnormal splenic cell ratio ( J:79946 )

• in adults, number of viable splenocytes in transgenic spleens is dramatically lower than in controls; proportion of IgG-positive cells is reduced while IgD-positive cells are slightly increased

skeleton

scoliosis ( J:79946 )

• mice often develop scoliosis of the back

cellular

increased neuron apoptosis ( J:79946 )

• majority of neurons in lumbar DRG have pyknotic nuclei

increased splenocyte apoptosis ( J:79946 )

• transgenic mice have 3-fold more apoptotic cells in the spleen compared to controls

homeostasis/metabolism

amyloidosis ( J:79946 )

• amyloid deposits are seen in sarcoplasm of skeletal muscle

Allelic Composition	Tg(CMV-IgkvaD11)BCat/Tg(CMV-IgkvaD11)BCat
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal object recognition memory ( J:210074 )

• at 6 and 12-14 months of age, but not 3 months, mice do not distinguish between old and new objects in the object recognition test, exploring the new and familiar object equally

impaired spatial learning ( J:210074 )

• during the acquisition phase of the Morris water maze, 12 month old mutants do not learn as well as wild-type mice

• during the probe phase of the Morris water maze, 3, 6, and 12-14 month old mice are unable to remember the target quadrant

homeostasis/metabolism

amyloid beta deposits ( J:210074 )

• amyloid beta immunoreactive dystrophic neurites in the hippocampus are first seen at 3 months of age and in the neocortex at 12-14 months of age

nervous system

amyloid beta deposits ( J:210074 )

• amyloid beta immunoreactive dystrophic neurites in the hippocampus are first seen at 3 months of age and in the neocortex at 12-14 months of age

tau protein deposits ( J:210074 )

• phosphorylated tau is seen in neurons of the lateral entorhinal cortex at 3 months of age, with a prominent somatodendritic location, and spreads to neurons of other cortical and hippocampal regions with age

abnormal cholinergic neuron morphology ( J:210074 )

• decrease in the number of ChAT-positive neurons in the nucleus basalis of Meynert at 6 and 12-14 months of age and in the medial septum/diagonal band of Broca at 3, 6, and 12-14 months

neuron degeneration ( J:210074 )

• degeneration of cholinergic neurons

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:210074

Allelic Composition	Tg(CMV-IgkvaD11)BCat/Tg(CMV-IgkvaD11)BCat
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal object recognition memory ( J:212312 )

• 6 month old mice do not preferentially explore the new object during an object recognition test, spending an equal time exploring the new and the old object

cardiovascular system

impaired blood-brain barrier function ( J:212312 )

• the blood brain barrier shows increased permeability

homeostasis/metabolism

amyloid beta deposits ( J:212312 )

• intraneuronal amyloid beta is seen in the stratum radiatum and molecularis of the hippocampus, starting from 6 months of age

nervous system

impaired blood-brain barrier function ( J:212312 )

• the blood brain barrier shows increased permeability

amyloid beta deposits ( J:212312 )

• intraneuronal amyloid beta is seen in the stratum radiatum and molecularis of the hippocampus, starting from 6 months of age

small superior cervical ganglion ( J:212312 )

• size of the superior cervical ganglion is decreased due to extensive shrinkage of cell body

abnormal brain morphology ( J:212312 )

• free nerve growth factor (NGF) in the brain is reduced by 50% compared to wild-type mice

• mice show hybrid anti-NGF antibodies (human light chain and endogenous mouse heavy chain) that are first detected between 1.5 and 2 months of age, both in serum and in the brain

neurofibrillary tangles ( J:212312 )

• neurofibrillary alterations

tau protein deposits ( J:212312 )

• age-dependent increase of immunoreactivity against phosphorylated tau in the cortex and in the pyramidal layer of the hippocampus

• phosphorylated-tau immunoreactivity is mainly located in the neuronal cell bodies or in apical dendrites

abnormal innervation ( J:212312 )

• expression of tyrosine hydroxylase in perivascular sympathetic nerve fibers innervating the wall of the posterior cerebral arteries is decreased, indicating decreased innervation of the large cerebral arteries

abnormal cholinergic neuron morphology ( J:212312 )

• decrease in the number of ChAT-positive cholinergic neurons in the medial septum and diagonal band of Broca as early as 2 months of age

• morphology of cholinergic neurons in the medial septum is altered, with most of the neurons being shrunk

• peripherally administered nerve growth factor prevents cholinergic neuron degeneration

neurodegeneration ( J:212312 )

• cholinergic neuron degeneration

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:212312

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