Analysis Tools
immune system
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• levels of neutrophil infiltration in a thioglycollate-induced peritonitis model are decreased by 70% after 2 hours and the peak infiltration is shifted to 6 hours post-treatment indicating a delay in extravasation
• however, neutrophil recruitment is still sensitive to Pecam1 and platelet depletion, and lymphocyte recruitment following IL-1beta and CCL19-stimulation is normal
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• following stimulation with TNF-alpha for 4 hours, leukocyte extravasation is reduced by 50% compared to in wild-type mice
• however, rolling and adherent cell numbers are normal following stimulation with TNF-alpha or IL-1beta for 4 hours
• following stimulation with IL-1beta for 4 hours, leukocyte extravasation is reduced by 45% compared to in wild-type mice
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cardiovascular system
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• following treatment with thiogycollate, less Evan's blue dye leaks into the peritoneum at 2 hours but levels recover by 4 hours
• permeability induced by VEGF-stimulation is less strong than in wild-type mice
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growth/size/body
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• mice have a 10% reduction in body weight compared to wild-type mice
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cellular
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• levels of neutrophil infiltration in a thioglycollate-induced peritonitis model are decreased by 70% after 2 hours and the peak infiltration is shifted to 6 hours post-treatment indicating a delay in extravasation
• however, neutrophil recruitment is still sensitive to Pecam1 and platelet depletion, and lymphocyte recruitment following IL-1beta and CCL19-stimulation is normal
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• following stimulation with TNF-alpha for 4 hours, leukocyte extravasation is reduced by 50% compared to in wild-type mice
• however, rolling and adherent cell numbers are normal following stimulation with TNF-alpha or IL-1beta for 4 hours
• following stimulation with IL-1beta for 4 hours, leukocyte extravasation is reduced by 45% compared to in wild-type mice
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hematopoietic system
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• levels of neutrophil infiltration in a thioglycollate-induced peritonitis model are decreased by 70% after 2 hours and the peak infiltration is shifted to 6 hours post-treatment indicating a delay in extravasation
• however, neutrophil recruitment is still sensitive to Pecam1 and platelet depletion, and lymphocyte recruitment following IL-1beta and CCL19-stimulation is normal
|
|
• following stimulation with TNF-alpha for 4 hours, leukocyte extravasation is reduced by 50% compared to in wild-type mice
• however, rolling and adherent cell numbers are normal following stimulation with TNF-alpha or IL-1beta for 4 hours
• following stimulation with IL-1beta for 4 hours, leukocyte extravasation is reduced by 45% compared to in wild-type mice
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