Phenotypes associated with this allele

• Allele Symbol: Nmur2^tm1Rtor
• Allele Name: targeted mutation 1, Richard Torres
• Allele ID: MGI:3722114
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nmur2^tm1Rtor/Nmur2^tm1Rtor	involves: 129S1/Sv * C57BL/6NTac	MGI:3722691
cx2	Nmur1^tm1Rtor/Nmur1^tm1Rtor Nmur2^tm1Rtor/Nmur2^tm1Rtor	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6NCr * C57BL/6NTac	MGI:3722690

Genotype
MGI:3722691

hm1

• Allelic Composition: Nmur2^tm1Rtor/Nmur2^tm1Rtor
• Genetic Background: involves: 129S1/Sv * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased chemical nociceptive threshold ( J:124469 )

• following injection of capsaicin or formalin in the hindpaw, mice display a 39% and 38% reduction, respectively, in targeted chronic pain behavior (licking)

• mice exhibit attenuation of hyperalgesia induced by intradermal injection of capsaicin and exposure to a hot plate after 90 minutes compared to wild-type mice that had a 53% reduction in latency when compared to the 15 minute time point

• however, response to injection of complete Freund's adjuvant is the same as in wild-type mice

increased thermal nociceptive threshold ( J:124469 )

• using a hot plate test, latency to respond is increased relative to in wild-type mice

Genotype
MGI:3722690

cx2

• Allelic Composition: Nmur1^tm1Rtor/Nmur1^tm1Rtor; Nmur2^tm1Rtor/Nmur2^tm1Rtor
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6NCr * C57BL/6NTac

behavior/neurological

increased thermal nociceptive threshold ( J:124469 )

• latency to respond to the hot plate test is increased relative to in wild-type mice but similar to in Nmur2^tm1Rtor homozygotes