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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ifna6tm1Aki
targeted mutation 1, Shizuo Akira
MGI:3722118
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ifna6tm1Aki/Ifna6+ Not Specified MGI:3808908
cx2
 		Ifna6tm1Aki/Ifna6+
Myd88tm1Aki/Myd88tm1Aki 		involves: 129P2/OlaHsd MGI:3808910
cx3
 		Mavstm1Aki/Mavstm1Aki
Ifna6tm1Aki/Ifna6+ 		involves: 129P2/OlaHsd MGI:3808911


Genotype
MGI:3808908
ht1
Allelic
Composition		 Ifna6tm1Aki/Ifna6+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifna6tm1Aki mutation (0 available); any Ifna6 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:124340 )
• mice are viable and fertile
• production of IFNalpha in response to viral infection is unimpaired




Genotype
MGI:3808910
cx2
Allelic
Composition		 Ifna6tm1Aki/Ifna6+
Myd88tm1Aki/Myd88tm1Aki
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifna6tm1Aki mutation (0 available); any Ifna6 mutation (16 available)
Myd88tm1Aki mutation (9 available); any Myd88 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal plasmacytoid dendritic cell morphology ( J:124340 )
• there is more than a 10-fold drop in the percentage of plasmacytoid dendritic cells that are GFP+ in response to Newcastle disease virus (NDV) infection when compared to controls
decreased interferon-alpha secretion ( J:124340 )
• levels of IFN-alpha are decreased 2 to 12 hours after infection with NDV compared to controls

hematopoietic system
abnormal plasmacytoid dendritic cell morphology ( J:124340 )
• there is more than a 10-fold drop in the percentage of plasmacytoid dendritic cells that are GFP+ in response to Newcastle disease virus (NDV) infection when compared to controls




Genotype
MGI:3808911
cx3
Allelic
Composition		 Mavstm1Aki/Mavstm1Aki
Ifna6tm1Aki/Ifna6+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifna6tm1Aki mutation (0 available); any Ifna6 mutation (16 available)
Mavstm1Aki mutation (0 available); any Mavs mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal myeloid dendritic cell morphology ( J:124340 )
• GFP+ conventional dendritic cell numbers are significantly lower compared to controls after NDV infection
abnormal macrophage morphology ( J:124340 )
• GFP+ macrophage numbers are significantly lower compared to controls after NDV infection
abnormal alveolar macrophage morphology ( J:124340 )
• GFP+ alveolar macrophage numbers are severely reduced after Newcastle disease virus (NDV) infection compared to controls
decreased interferon-alpha secretion ( J:124340 )
• levels of IFN-alpha are severely decreased 2 to 6 hours after infection with NDV compared to controls
• levels of IFN-alpha remain below what is found in controls for 24 hours after infection

hematopoietic system
abnormal myeloid dendritic cell morphology ( J:124340 )
• GFP+ conventional dendritic cell numbers are significantly lower compared to controls after NDV infection
abnormal macrophage morphology ( J:124340 )
• GFP+ macrophage numbers are significantly lower compared to controls after NDV infection
abnormal alveolar macrophage morphology ( J:124340 )
• GFP+ alveolar macrophage numbers are severely reduced after Newcastle disease virus (NDV) infection compared to controls

respiratory system
abnormal alveolar macrophage morphology ( J:124340 )
• GFP+ alveolar macrophage numbers are severely reduced after Newcastle disease virus (NDV) infection compared to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory