Analysis Tools
nervous system
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• fibrillar thioflavin-S positive amyloid plaques are significantly increased in subiculum region of brain compared to Tg(APPV717I)1130Kha single transgenics
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• decrease in vascular amyloid deposition is found in double transgenics relative to single mutant animals
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• by 15 months, subiculum is almost totally covered with diffuse and senile plaques
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• at 15 months and older, surface of cerebral cortex is occupied by thioflavin-S- and amyloid beta-positive deposits is 3-5-fold greater than in age-matched Tg(APPV717I)1130Kha mice
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• dystrophic neurites with swollen and distorted neuritic profiles are identified in brains of mice
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homeostasis/metabolism
amyloidosis
(
J:93635
)
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• total levels of intact amyloid beta-40 and-42 peptides are increased by ~3-fold in older mice relative to single transgenic mice
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• fibrillar thioflavin-S positive amyloid plaques are significantly increased in subiculum region of brain compared to Tg(APPV717I)1130Kha single transgenics
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• decrease in vascular amyloid deposition is found in double transgenics relative to single mutant animals
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:93635 | ||
