Phenotypes associated with this allele

• Allele Symbol: Cyld^tm1Jdgl
• Allele Name: targeted mutation 1, Jian-Dong Li
• Allele ID: MGI:3722146
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyld^tm1Jdgl/Cyld^tm1Jdgl	involves: 129 * C57BL/6J	MGI:3722770

Genotype
MGI:3722770

hm1

• Allelic Composition: Cyld^tm1Jdgl/Cyld^tm1Jdgl
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:124327 )

• following infection with Streptococcus pneumoniae and S. pneumoniae pneumolysin, mice exhibit an increased survival rate (87% in the case of S. pneumoniae infection at day 5) compared to infected wild-type mice (9% survival at 48 hours in the case of S. pneumoniae infection)

immune system

decreased susceptibility to bacterial infection ( J:124327 )

• following infection with PLY, mice do not display the acute long injury observed in infected wild-type mice

• following infection with S. pneumoniae, circulating bacterial counts are reduced

• however, treatment with inhibitors of Map2k3 and Serpine1 increase susceptibility of mice to S. pneumoniae infection

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:124327 )

• following infection with Streptococcus pneumoniae and S. pneumoniae pneumolysin, mice exhibit an increased survival rate (87% in the case of S. pneumoniae infection at day 5) compared to infected wild-type mice (9% survival at 48 hours in the case of S. pneumoniae infection)