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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nlrc4tm1Gln
targeted mutation 1, Jorge E Galan
MGI:3722152
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nlrc4tm1Gln/Nlrc4tm1Gln involves: 129S5/SvEvBrd MGI:5085875
cx2
 		Nlrc4tm1Gln/Nlrc4tm1Gln
Slc11a1s/Slc11a1s 		B6.129S5-Nlrc4tm1Gln MGI:3722758


Genotype
MGI:5085875
hm1
Allelic
Composition		 Nlrc4tm1Gln/Nlrc4tm1Gln
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4tm1Gln mutation (0 available); any Nlrc4 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:173245 )
N
• mice co-housed with wild-type mice do not affect the susceptibility to induced colitis of wild-type mice




Genotype
MGI:3722758
cx2
Allelic
Composition		 Nlrc4tm1Gln/Nlrc4tm1Gln
Slc11a1s/Slc11a1s
Genetic
Background		 B6.129S5-Nlrc4tm1Gln
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4tm1Gln mutation (0 available); any Nlrc4 mutation (69 available)
Slc11a1s mutation (0 available); any Slc11a1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:124378 )
• when infected with 105 Salmonella typhimurium, mice exhibit increased mortality similar to in Slc11a1s homozygotes
• when infected with 105 Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased similar to in Slc11a1s homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory