Analysis Tools
hematopoietic system
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• at day 450, blood smears of some mice display numerous immature myeloid progenitor cells in clumps and with a high nucleus to cytoplasm ratio
• the erythroid precursor compartment in the spleen and marrow is increased
at day 450, 4- to 6-fold more splenic erythroid precursors remain in S phase
• in 5% of mice blood smears are fibrotic
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• extramedullary hematopoiesis occurs in the spleen, liver and lungs via aggregates of plasma cells
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• at day 400, erythroid progenitor cells contain abnormal mitotic figures, abnormally high nucleus-to-cytoplasm ratios, and increased levels of monocytes and ring granulocytes
• in 5% of mice blood smears are fibrotic
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• at day 400, the bone marrow is hypercellular
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• at day 450, some mice display dysplastic erythrocytes characterized by echinocytosis
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• at day 450, mice suffer from lymphopenia
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• at day 450, white blood cell counts are elevated
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• at day 100, granolycyte number is increased
• at day 400, the bone marrow contains increased numbers of ring granulocytes
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• at day 100
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• at day 400, the bone marrow contains increased levels of monocytes
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• at day 100, spleen dysplasia is apparent
• congestion and necrosis are observed in the spleen
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• at 450 days
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• mice lack or have malformed germinal centers
• at day 100, hemosidirin levels are elevated and there is marked congestion, necrosis and extramedullary hematopoiesis via aggregates of plasma cells
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skeleton
malocclusion
(
J:124319
)
homeostasis/metabolism
dehydration
(
J:124319
)
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• mice show signs of dehydration
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craniofacial
malocclusion
(
J:124319
)
growth/size/body
malocclusion
(
J:124319
)
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• mice fail to thrive between 200 and 450 days
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• at 450 days
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immune system
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• at day 450, mice suffer from lymphopenia
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• at day 450, white blood cell counts are elevated
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• at day 100, granolycyte number is increased
• at day 400, the bone marrow contains increased numbers of ring granulocytes
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• at day 100
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• at day 400, the bone marrow contains increased levels of monocytes
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• at day 100, spleen dysplasia is apparent
• congestion and necrosis are observed in the spleen
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• at 450 days
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• mice lack or have malformed germinal centers
• at day 100, hemosidirin levels are elevated and there is marked congestion, necrosis and extramedullary hematopoiesis via aggregates of plasma cells
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• authors state that mice display similar lymph node defects as those seen in the spleen
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dermatitis
(
J:124319
)
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• mice exhibit granulated dermatitis and inflammation on paws
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integument
dermatitis
(
J:124319
)
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• mice exhibit granulated dermatitis and inflammation on paws
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• after 300 days, some mice develop alopecia
• one female exhibited alopecia on muzzle from excessive barbering
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• after 300 days, 30% to 40% of mice develop dermatoses
• one female exhibited dermatoses along crest from excessive barbering
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