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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd79btm1Gzmn
targeted mutation 1, Anna Gazumyan
MGI:3722155
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd79btm1Gzmn/Cd79btm1Gzmn involves: 129/Sv * C57BL/6 MGI:3722626
cx2
 		Cd79atm1.1Cgn/Cd79atm1.1Cgn
Cd79btm1Gzmn/Cd79btm1Gzmn 		involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:3722627
cx3
 		Cd79atm1.1Cgn/Cd79atm1.1Cgn
Cd79btm1Gzmn/Cd79btm1Gzmn 		involves: 129P2/OlaHsd MGI:5301878
cx4
 		Cd79atm1.1Cgn/Cd79atm1.1Cgn
Cd79btm1Gzmn/Cd79b+ 		involves: 129P2/OlaHsd MGI:5301880
cx5
 		Cd79atm1.1Cgn/Cd79a+
Cd79btm1Gzmn/Cd79btm1Gzmn 		involves: 129P2/OlaHsd MGI:5301881


Genotype
MGI:3722626
hm1
Allelic
Composition		 Cd79btm1Gzmn/Cd79btm1Gzmn
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79btm1Gzmn mutation (1 available); any Cd79b mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B-1a cell number ( J:124400 )
• the number of B-1a B cell is reduced five-fold relative to in wild-type mice
abnormal immune system physiology ( J:124400 )
• following exposure to NP-Ficcoll or NP-CGG (chicken gamma globulin), mice exhibit a small increase in IgG3 response to T-independent antibodies, no increase in proliferative responses to anti-IgM in vitro, and a slight decrease in T-dependent antibody responses
increased IgD level ( J:124400 )
• surface IgD levels on immature and recirculating B cells is increased
decreased IgG1 level ( J:124400 )
• IgG1 levels are decreased by five-fold relative to in wild-type mice
increased IgM level ( J:124400 )
• surface IgM levels on immature and recirculating B cells is increased
• IgM serum levels are increased three-fold relative to in wild-type mice
• following exposure to NP-Ficcoll or NP-CGG (chicken gamma globulin), NP-specific IgM antibodies are increased 10-fold

hematopoietic system
decreased B-1a cell number ( J:124400 )
• the number of B-1a B cell is reduced five-fold relative to in wild-type mice
increased IgD level ( J:124400 )
• surface IgD levels on immature and recirculating B cells is increased
decreased IgG1 level ( J:124400 )
• IgG1 levels are decreased by five-fold relative to in wild-type mice
increased IgM level ( J:124400 )
• surface IgM levels on immature and recirculating B cells is increased
• IgM serum levels are increased three-fold relative to in wild-type mice
• following exposure to NP-Ficcoll or NP-CGG (chicken gamma globulin), NP-specific IgM antibodies are increased 10-fold




Genotype
MGI:3722627
cx2
Allelic
Composition		 Cd79atm1.1Cgn/Cd79atm1.1Cgn
Cd79btm1Gzmn/Cd79btm1Gzmn
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1.1Cgn mutation (0 available); any Cd79a mutation (24 available)
Cd79btm1Gzmn mutation (1 available); any Cd79b mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:124400 )
• B cells fail to develop beyond the pro-B cell stage

hematopoietic system
abnormal B cell differentiation ( J:124400 )
• B cells fail to develop beyond the pro-B cell stage




Genotype
MGI:5301878
cx3
Allelic
Composition		 Cd79atm1.1Cgn/Cd79atm1.1Cgn
Cd79btm1Gzmn/Cd79btm1Gzmn
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1.1Cgn mutation (0 available); any Cd79a mutation (24 available)
Cd79btm1Gzmn mutation (1 available); any Cd79b mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:179254 )
• mice exhibit impaired pre-B and later stage B cell development unlike either single homozygote
decreased B cell number ( J:179254 )
• IgM+ B cells

hematopoietic system
abnormal B cell differentiation ( J:179254 )
• mice exhibit impaired pre-B and later stage B cell development unlike either single homozygote
decreased B cell number ( J:179254 )
• IgM+ B cells




Genotype
MGI:5301880
cx4
Allelic
Composition		 Cd79atm1.1Cgn/Cd79atm1.1Cgn
Cd79btm1Gzmn/Cd79b+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1.1Cgn mutation (0 available); any Cd79a mutation (24 available)
Cd79btm1Gzmn mutation (1 available); any Cd79b mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:179254 )
• IgM+ B cells

hematopoietic system
decreased B cell number ( J:179254 )
• IgM+ B cells




Genotype
MGI:5301881
cx5
Allelic
Composition		 Cd79atm1.1Cgn/Cd79a+
Cd79btm1Gzmn/Cd79btm1Gzmn
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1.1Cgn mutation (0 available); any Cd79a mutation (24 available)
Cd79btm1Gzmn mutation (1 available); any Cd79b mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:179254 )
• IgM+ B cells

hematopoietic system
decreased B cell number ( J:179254 )
• IgM+ B cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory