Phenotypes associated with this allele

• Allele Symbol: Or2b4^tm4Mom
• Allele Name: targeted mutation 4, Peter Mombaerts
• Allele ID: MGI:3722376
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Or2b4^tm4Mom/Or2b4^tm4Mom	B6;129P2-Or2b4^tm4Mom/MomJ	MGI:4367781

Genotype
MGI:4367781

hm1

• Allelic Composition: Or2b4^tm4Mom/Or2b4^tm4Mom
• Genetic Background: B6;129P2-Or2b4^tm4Mom/MomJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal olfactory sensory neuron morphology ( J:154360 )

• the density of olfactory sensory neurons with the Olfr124 locus actively transcribed is 14 times lower than normal in the septal organ

• lacking the endogenous OLFR124 protein, olfactory sensory neurons actively transcribing this locus have significantly reduced response to odorants that stimulate olfactory sensory neurons expressing normal OLFR124

abnormal olfactory receptor morphology ( J:154360 )

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:154360 )

• the density of olfactory sensory neurons with the Olfr124 locus actively transcribed is 14 times lower than normal in the septal organ

• lacking the endogenous OLFR124 protein, olfactory sensory neurons actively transcribing this locus have significantly reduced response to odorants that stimulate olfactory sensory neurons expressing normal OLFR124

abnormal olfactory receptor morphology ( J:154360 )

craniofacial

abnormal olfactory sensory neuron morphology ( J:154360 )

• the density of olfactory sensory neurons with the Olfr124 locus actively transcribed is 14 times lower than normal in the septal organ

• lacking the endogenous OLFR124 protein, olfactory sensory neurons actively transcribing this locus have significantly reduced response to odorants that stimulate olfactory sensory neurons expressing normal OLFR124

abnormal olfactory receptor morphology ( J:154360 )

respiratory system

abnormal olfactory sensory neuron morphology ( J:154360 )

• the density of olfactory sensory neurons with the Olfr124 locus actively transcribed is 14 times lower than normal in the septal organ

• lacking the endogenous OLFR124 protein, olfactory sensory neurons actively transcribing this locus have significantly reduced response to odorants that stimulate olfactory sensory neurons expressing normal OLFR124

abnormal olfactory receptor morphology ( J:154360 )

growth/size/body

abnormal olfactory sensory neuron morphology ( J:154360 )

• the density of olfactory sensory neurons with the Olfr124 locus actively transcribed is 14 times lower than normal in the septal organ

• lacking the endogenous OLFR124 protein, olfactory sensory neurons actively transcribing this locus have significantly reduced response to odorants that stimulate olfactory sensory neurons expressing normal OLFR124

abnormal olfactory receptor morphology ( J:154360 )