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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Or51e2tm1Mom
targeted mutation 1, Peter Mombaerts
MGI:3722382
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Or51e2tm1Mom/Or51e2tm1Mom involves: 129P2/OlaHsd * C57BL/6J MGI:5903955
ot2
Or51e2tm1Mom/? involves: 129P2/OlaHsd * C57BL/6J MGI:3830819


Genotype
MGI:5903955
hm1
Allelic
Composition
Or51e2tm1Mom/Or51e2tm1Mom
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or51e2tm1Mom mutation (1 available); any Or51e2 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• although the number and morphology of glomus cells is normal, no significant changes in respiratory rate or minute ventilation occur in response to hypoxia of 10% oxygen, the partial pressure of CO2 in arterial blood is incresed an pH decreased, but ventilary and locomotor responses to hypercapnia of 5% CO2 remain normal
• although the carotid sinus nerves respond to low pH they do not respond to hypoxia, lactate, acetate, or proprionate

respiratory system




Genotype
MGI:3830819
ot2
Allelic
Composition
Or51e2tm1Mom/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or51e2tm1Mom mutation (1 available); any Or51e2 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in addition to the normal pattern of axonal projection to glomeruli in the dorsal-medial and anterior-medial olfactory bulb, there is innervation of glomeruli at the caudal margins of the olfactory bulb, which is not found when this olfactory receptor is intact





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory