Phenotypes associated with this allele

• Allele Symbol: Htr7^tm1Wtkn
• Allele Name: targeted mutation 1, Jeffrey M Witkin
• Allele ID: MGI:3722446
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Htr7^tm1Wtkn/Htr7^tm1Wtkn	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3723592

Genotype
MGI:3723592

hm1

• Allelic Composition: Htr7^tm1Wtkn/Htr7^tm1Wtkn
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:124549 )

• death resulted from cocaine administration in mutant mice but not in wild-type control

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:124549 )

• pentylenetetrazole and cocaine was more potent in inducing seizures

abnormal seizure response to electrical stimulation ( J:124549 )

• thresholds for producing electroshock-induced tonic seizure were significantly lower

• thresholds for producing electroshock-induced clonic seizure did not fifer between mutant versus wild-type

nervous system

increased susceptibility to pharmacologically induced seizures ( J:124549 )

• pentylenetetrazole and cocaine was more potent in inducing seizures

abnormal seizure response to electrical stimulation ( J:124549 )

• thresholds for producing electroshock-induced tonic seizure were significantly lower

• thresholds for producing electroshock-induced clonic seizure did not fifer between mutant versus wild-type

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:124549 )

• death resulted from cocaine administration in mutant mice but not in wild-type control