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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tpsb2tm1(cre)Adch
targeted mutation 1, Roberto Adachi
MGI:3722523
Summary 2 genotypes


Genotype
MGI:3723511
hm1
Allelic
Composition		 Tpsb2tm1(cre)Adch/Tpsb2tm1(cre)Adch
Genetic
Background		 B6.Cg-Tpsb2tm1(cre)Adch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpsb2tm1(cre)Adch mutation (0 available); any Tpsb2 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:124554 )
• a substantially reduced ability to combat K. pneumoniae infections of their peritoneal cavities
• produced normal-sized litters, showed no obvious developmental abnormality, and had a normal lifespan when maintained in a pathogen-free animal facility
• the peritoneal mast cells showed no substantial alteration in their size or shape or in the numbers, size and density of their secretory granules




Genotype
MGI:3828167
cx2
Allelic
Composition		 Tpsab1m1/Tpsab1m1
Tpsb2tm1(cre)Adch/Tpsb2tm1(cre)Adch
Genetic
Background		 B6.Cg-Tpsb2tm1(cre)Adch Tpsab1m1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpsab1m1 mutation (0 available); any Tpsab1 mutation (15 available)
Tpsb2tm1(cre)Adch mutation (0 available); any Tpsb2 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell differentiation ( J:142880 )
• synovial mast cells do not express the mMcp-6 and -7 proteases
decreased susceptibility to induced arthritis ( J:142880 )
• there is a signifcant decrease in clinical measurements of joint inflammation induced by Tg(TcraR28,TcrbR28)KRNDim (i.e. K/BxN) mouse serum compared to C57BL/6 controls
• ankle thickness is also less than controls 10 days after arthritis induction
• histological scores of bone and cartilage erosion, as well as inflammation, are also significantly reduced

skeleton
decreased susceptibility to induced arthritis ( J:142880 )
• there is a signifcant decrease in clinical measurements of joint inflammation induced by Tg(TcraR28,TcrbR28)KRNDim (i.e. K/BxN) mouse serum compared to C57BL/6 controls
• ankle thickness is also less than controls 10 days after arthritis induction
• histological scores of bone and cartilage erosion, as well as inflammation, are also significantly reduced

hematopoietic system
abnormal mast cell differentiation ( J:142880 )
• synovial mast cells do not express the mMcp-6 and -7 proteases

cellular
abnormal mast cell differentiation ( J:142880 )
• synovial mast cells do not express the mMcp-6 and -7 proteases




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory