About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Clca1tm1Dgen
targeted mutation 1, Deltagen
MGI:3722629
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Clca1tm1Dgen/Clca1tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3723241


Genotype
MGI:3723241
hm1
Allelic
Composition		 Clca1tm1Dgen/Clca1tm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clca1tm1Dgen mutation (0 available); any Clca1 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal inflammatory response ( J:112942 )
• in two asthma models, mice fail to attenuate the inflammatory response after allergen (ovalbumin) challenge
• following exposure to ovalbumin, mice develop an exacerbated mucin secretory response compared to wild-type mice
• following exposure to ovalbumin or IL-13, Muc5ac levels are increased compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory