Phenotypes associated with this allele

• Allele Symbol: Cyp17a1^tm1Vpap
• Allele Name: targeted mutation 1, Vassilios Papadopoulos
• Allele ID: MGI:3722780
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cyp17a1^tm1Vpap/Cyp17a1^+	chimera involves: 129X1/SvJ * C57BL/6	MGI:4430249

Genotype
MGI:4430249

ht1

• Allelic Composition: Cyp17a1^tm1Vpap/Cyp17a1⁺
• Genetic Background: chimera involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

early reproductive senescence ( J:100434 )

• male chimeras cease mating over time

reproductive system

abnormal sperm flagellum morphology ( J:100434 )

♂ • some sperm are bent between the middle and end piece and/or have looped tails unlike in wild-type mice

asthenozoospermia ( J:100434 )

♂ • in a swim-up test, 50% of sperm fail to swim-up unlike wild-type sperm

early reproductive senescence ( J:100434 )

• male chimeras cease mating over time

transmission ratio distortion ( J:100434 )

• male chimeras fail to produce heterozygotes bearing the allele

reduced male fertility ( J:100434 )

♂ • male chimeras cease mating over time

homeostasis/metabolism

abnormal testosterone level ( J:100434 )

• testosterone levels in Leydig cells of chimeric males is decreased 80% compared to in wild-type mice

decreased circulating testosterone level ( J:100434 )

• in male chimeras

behavior/neurological

abnormal sexual interaction ( J:100434 )

• male chimeras cease mating over time

cellular

abnormal sperm flagellum morphology ( J:100434 )

♂ • some sperm are bent between the middle and end piece and/or have looped tails unlike in wild-type mice

asthenozoospermia ( J:100434 )

♂ • in a swim-up test, 50% of sperm fail to swim-up unlike wild-type sperm