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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr299391tm1.1Fwa
targeted mutation 1.1, Frederick W Alt
MGI:3722842
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr299391tm1.1Fwa/Rr299391tm1.1Fwa involves: 129P2/OlaHsd * FVB/N MGI:3723205
ht2
 		Rr299391tm1.1Fwa/Rr299391+ involves: 129P2/OlaHsd * FVB/N MGI:3723206
cx3
 		Rag2tm1Fwa/Rag2tm1Fwa
Rr299391tm1.1Fwa/Rr299391tm1.1Fwa 		involves: 129P2/OlaHsd * 129S/SvEv MGI:3849290


Genotype
MGI:3723205
hm1
Allelic
Composition		 Rr299391tm1.1Fwa/Rr299391tm1.1Fwa
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell number ( J:55401 )
• splenic T cells and thymocytes are reduced 8- to 10-fold and 10- to 15-fold, respectively, compared to in wild-type mice
decreased thymocyte number ( J:55401 )
• thymocytes are reduced 8- to 10-fold compared to in wild-type mice

hematopoietic system
decreased T cell number ( J:55401 )
• splenic T cells and thymocytes are reduced 8- to 10-fold and 10- to 15-fold, respectively, compared to in wild-type mice
decreased thymocyte number ( J:55401 )
• thymocytes are reduced 8- to 10-fold compared to in wild-type mice

endocrine/exocrine glands
decreased thymocyte number ( J:55401 )
• thymocytes are reduced 8- to 10-fold compared to in wild-type mice




Genotype
MGI:3723206
ht2
Allelic
Composition		 Rr299391tm1.1Fwa/Rr299391+
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell number ( J:55401 )
• splenic T cells and thymocytes are reduced 1.5- to 2-fold and 2- to 3-fold, respectively, compared to in wild-type mice
decreased thymocyte number ( J:55401 )
• thymocytes are reduced 1.5- to 2-fold compared to in wild-type mice

hematopoietic system
decreased T cell number ( J:55401 )
• splenic T cells and thymocytes are reduced 1.5- to 2-fold and 2- to 3-fold, respectively, compared to in wild-type mice
decreased thymocyte number ( J:55401 )
• thymocytes are reduced 1.5- to 2-fold compared to in wild-type mice

endocrine/exocrine glands
decreased thymocyte number ( J:55401 )
• thymocytes are reduced 1.5- to 2-fold compared to in wild-type mice




Genotype
MGI:3849290
cx3
Allelic
Composition		 Rag2tm1Fwa/Rag2tm1Fwa
Rr299391tm1.1Fwa/Rr299391tm1.1Fwa
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (119 available)
Rr299391tm1.1Fwa mutation (0 available); any Rr299391 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell receptor delta chain V(D)J recombination ( J:149413 )
• transcript analysis of double-negative thymocytes reveals a 10-fold drop in use of the Tcrd-V5 gene segment

hematopoietic system
abnormal T cell receptor delta chain V(D)J recombination ( J:149413 )
• transcript analysis of double-negative thymocytes reveals a 10-fold drop in use of the Tcrd-V5 gene segment




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory