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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mrc2tm1Cmi
targeted mutation 1, Clare M Isacke
MGI:3722867
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mrc2tm1Cmi/Mrc2tm1Cmi involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3723180
cx2
 		Mrc1tm1Mnz/Mrc1tm1Mnz
Mrc2tm1Cmi/Mrc2tm1Cmi 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:3723179


Genotype
MGI:3723180
hm1
Allelic
Composition		 Mrc2tm1Cmi/Mrc2tm1Cmi
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrc2tm1Cmi mutation (4 available); any Mrc2 mutation (120 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased fibroblast cell migration ( J:124909 )
• mouse embryonic fibroblast (MEF) cells from E13.5 embryos exhibit decreased migratory speed in a Dunn chamber assay compared to wild-type MEFs




Genotype
MGI:3723179
cx2
Allelic
Composition		 Mrc1tm1Mnz/Mrc1tm1Mnz
Mrc2tm1Cmi/Mrc2tm1Cmi
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrc1tm1Mnz mutation (1 available); any Mrc1 mutation (86 available)
Mrc2tm1Cmi mutation (4 available); any Mrc2 mutation (120 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:124290 )
• bone marrow macrophages are defective in binding and internalizing OG-gelatin
• bone marrow macrophages have increased migration speed relative to control cells

hematopoietic system
abnormal macrophage physiology ( J:124290 )
• bone marrow macrophages are defective in binding and internalizing OG-gelatin
• bone marrow macrophages have increased migration speed relative to control cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory