Analysis Tools
immune system
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• neutrophils display reduced chemotactic response to chemokines (CCL5 and CXCL8) and chemoattractants (C5a) in a Boyden chambers analysis
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• in a septic peritonitis model or Escherichia urinary tract model, neutrophil counts are decreased at 12 hours after infection
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• in a septic peritonitis model or Escherichia urinary tract model, macrophage counts are decreased at 12 hours after infection
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• mice exhibit generalized leukocytosis
• bone marrow-derived macrophages incorporate more thymidine than wild-type mice when stimulated with GM-CSF (granulocyte monocyte colony stimulating factor) and CSF-1 (colony stimulating factor)
• leukocyte apoptosis is decreased in neutrophils and macrophages by 40% and 56%, respectively
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• peritoneal macrophages stimulated with LPS produce increased amounts of IL-1beta, IL-6 and TNF-alpha compared to wild-type mice
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• bone marrow-derived macrophages display reduced chemotactic response to chemokines (CCL5 and CXCL8) and chemoattractants (C5a) in a Boyden chambers analysis
• in a Dunn chamber assay bone marrow-derived macrophages show a less persistent orientation towards the gradient of CCL5, C5a and CSF-1 (colony stimulating factor) than wild-type cells
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• peritoneal macrophages stimulated with LPS produce increased amounts of IL-1beta compared to wild-type mice
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• peritoneal macrophages stimulated with LPS produce increased amounts of IL-6 compared to wild-type mice
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• peritoneal macrophages stimulated with LPS produce increased amounts of TNF-alpha compared to wild-type mice
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• resolution of inflammatory reaction and clearance of granulation is delayed in a wound healing assay because of a 2-fold decrease in apoptotic removal of inflammatory cells
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hematopoietic system
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• neutrophils display reduced chemotactic response to chemokines (CCL5 and CXCL8) and chemoattractants (C5a) in a Boyden chambers analysis
|
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• in a septic peritonitis model or Escherichia urinary tract model, neutrophil counts are decreased at 12 hours after infection
|
|
• in a septic peritonitis model or Escherichia urinary tract model, macrophage counts are decreased at 12 hours after infection
|
|
• mice exhibit generalized leukocytosis
• bone marrow-derived macrophages incorporate more thymidine than wild-type mice when stimulated with GM-CSF (granulocyte monocyte colony stimulating factor) and CSF-1 (colony stimulating factor)
• leukocyte apoptosis is decreased in neutrophils and macrophages by 40% and 56%, respectively
|
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• peritoneal macrophages stimulated with LPS produce increased amounts of IL-1beta, IL-6 and TNF-alpha compared to wild-type mice
|
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• bone marrow-derived macrophages display reduced chemotactic response to chemokines (CCL5 and CXCL8) and chemoattractants (C5a) in a Boyden chambers analysis
• in a Dunn chamber assay bone marrow-derived macrophages show a less persistent orientation towards the gradient of CCL5, C5a and CSF-1 (colony stimulating factor) than wild-type cells
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integument
skin lesions
(
J:124856
)
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• mice develop spontaneous skin lesions with accumulation of inflammatory cells
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cellular
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• bone marrow-derived macrophages display reduced chemotactic response to chemokines (CCL5 and CXCL8) and chemoattractants (C5a) in a Boyden chambers analysis
• in a Dunn chamber assay bone marrow-derived macrophages show a less persistent orientation towards the gradient of CCL5, C5a and CSF-1 (colony stimulating factor) than wild-type cells
|
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• neutrophils display reduced chemotactic response to chemokines (CCL5 and CXCL8) and chemoattractants (C5a) in a Boyden chambers analysis
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