Phenotypes associated with this allele

• Allele Symbol: Scp2^tm1Kier
• Allele Name: targeted mutation 1, Ann B Kier
• Allele ID: MGI:3722944
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scp2^tm1Kier/Scp2^tm1Kier	involves: 129P2/OlaHsd * C57BL/6NCr	MGI:3723068

Genotype
MGI:3723068

hm1

• Allelic Composition: Scp2^tm1Kier/Scp2^tm1Kier
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid level ( J:124895 )

• the neutral lipid levels (triglycerides and cholesterol ester) are decreased in male and female mice relative to wild-type mice

• when fed a phytol-rich diet, the neutral lipid levels are decreased in female mice

increased circulating cholesterol level ( J:124895 )

• serum cholesterol levels in male mice is increased (18+/-2 compared to 11+/-1 in wild-type males)

• however, serum cholesterol levels plus total cholesterol is similar to in wild-type mice

decreased circulating triglyceride level ( J:124895 )

• fasting serum triglyceride levels are decreased in male mice (3+/-1 compared to 8+/-1 in wild-type mice)

increased fatty acids level ( J:124895 )

• free fatty acid levels in the liver are increased in female mice (163+/-14 compared to 216+/-17 in wild-type mice)

decreased liver triglyceride level ( J:124895 )

• liver triglyceride levels are decreased in female mice (154+/-25 compared to 265+/-24 in wild-type mice)

growth/size/body

decreased lean body mass ( J:124895 )

• when fed a phytol-rich diet, lean tissue mass is reduced by 1.4-fold in males and 1.2-fold in females compared to in wild-type mice (1.3-flod in females)

increased susceptibility to weight loss ( J:124895 )

• when fed a phytol-rich diet, both male and female mice exhibit a 24% to 26% weight loss despite consuming the same amount of food as wild-type, in which only females are sensitive to phytol-rich diets

enlarged liver ( J:124895 )

• when fed a phytol-rich diet, males and females exhibit an enlarged liver compared to only female wild-type mice

liver/biliary system

liver inflammation ( J:124895 )

• when fed a phytol-rich diet, males and females exhibit necrosis, fatty vacuolation and inflammation in the liver compared to only female wild-type mice

abnormal liver morphology ( J:124895 )

• when fed a phytol-rich diet, the amount of fat droplets in the livers of males is decreased compared to wild-type male mice

enlarged liver ( J:124895 )

• when fed a phytol-rich diet, males and females exhibit an enlarged liver compared to only female wild-type mice

decreased liver triglyceride level ( J:124895 )

• liver triglyceride levels are decreased in female mice (154+/-25 compared to 265+/-24 in wild-type mice)

decreased hepatocyte number ( J:124895 )

• when fed a phytol-rich diet, males and females exhibit loss of hepatocytes compared to only female wild-type mice

adipose tissue

decreased total body fat amount ( J:124895 )

• when fed a phytol-rich diet, fat tissue mass is reduced by 7.6-fold in males and 3.5-fold in females compared to in wild-type mice (3.0-fold in females)

immune system

liver inflammation ( J:124895 )

• when fed a phytol-rich diet, males and females exhibit necrosis, fatty vacuolation and inflammation in the liver compared to only female wild-type mice