Analysis Tools|
Allele Symbol Allele Name Allele ID |
Sulf2tm1.1Cpe targeted mutation 1.1, Charles P Emerson, Jr MGI:3722946 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 1% to 2% of mice exhibit megaesophagus
|
|
• 1% to 2% of mice exhibit megaesophagus
|
|
• mice weigh 10% less than wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice begin to die at P14 and only 45% of mice survive into adulthood
|
|
• mice display reduced fertility
|
|
• some adult mice exhibit dilation of the muscle layers and esophageal epithelium
• at P15, the lumen of the esophagus is increased by 20% compared to wild-type mice
• in adults, the lumen of the esophagus is almost double the size of that in wild-type mice
|
|
• 60% of mice exhibit megaesophagus characterized by food accumulating in the esophagus, coughing, labored breathing and lung infection
|
|
• esophageal smooth muscle contractility induced by carbachol is greatly reduced and that induced by high potassium, ATP and histamine is partially reduced
|
|
• at P15 and in adults mice, the number of glial cells in the esophagus is one third of that found in wild-type mice
|
|
• at E18.5, neurite sprouting and innervation density in esophageal tissue is reduced
• reduced innervation persists postnatally and into adulthood
• esophageal explants from E11.5 embryos fail to extend neuritis when treated with 10 ng/ml GDNF and only extend half the number of neuritis that wild-type explants do at 20 ng/ml of GDNF
• however, explants treated with 10 mg/ml GDNF have the same number of intrinsic neurons as controls
• no neurons migrate out of explants after GDNF treatment compared to a few in treated wild-type explants
|
|
• esophageal smooth muscle contractility induced by carbachol is greatly reduced and that induced by high potassium, ATP and histamine is partially reduced
|
|
• 60% of mice exhibit megaesophagus characterized by food accumulating in the esophagus, coughing, labored breathing and lung infection
|
|
• mice that survive into adulthood are runted
|
|
• as early as P3, mice exhibit a postnatal growth retardation likely due to a defect in esophagus innervation
|
|
• 60% of mice exhibit labored breathing associated with megaesophagus
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/19/2024 MGI 6.24 |
|
|
|
||
