Phenotypes associated with this allele

• Allele Symbol: Bche^tm1Loc
• Allele Name: targeted mutation 1, Oksana Lockridge
• Allele ID: MGI:3723049
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bche^tm1Loc/Bche^tm1Loc	involves: 129S1/Sv	MGI:3723137
ht2	Bche^tm1Loc/Bche^+	involves: 129S1/Sv	MGI:3848447

Genotype
MGI:3723137

hm1

• Allelic Composition: Bche^tm1Loc/Bche^tm1Loc
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:130048 )

• donepezil-treated mice die within 3 hours unlike similarly treated controls

• (-)-huperzin A-treated mice die within 10 minutes unlike similarly treated controls

reproductive system

reproductive system phenotype ( J:124975 )

N • mice are fertile

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:130048 )

• donepezil-treated mice die within 3 hours unlike similarly treated controls

• (-)-huperzin A-treated mice die within 10 minutes unlike similarly treated controls

increased physiological sensitivity to xenobiotic ( J:130048 )

• treatment with donepezil induces clonic, jerking convulsions and death within 3 hours unlike similarly treated wild-type mice that recover within 24 hours

• (-)-huperzin A-treated mice exhibit protosis, salivation, and lacrimation with death occurring within 10 minutes of treatment unlike similarly treated mice

• however, mice exhibit a normal reaction to CPO and echothiophate

Genotype
MGI:3848447

ht2

• Allelic Composition: Bche^tm1Loc/Bche⁺
• Genetic Background: involves: 129S1/Sv

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:130048 )

• donepezil-treated mice die within 24 hours unlike similarly treated controls

• (-)-huperzin A-treated mice die within 24 hours unlike similarly treated controls

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:130048 )

• donepezil-treated mice die within 24 hours unlike similarly treated controls

• (-)-huperzin A-treated mice die within 24 hours unlike similarly treated controls

increased physiological sensitivity to xenobiotic ( J:130048 )

• treatment with donepezil induces intermediate symptoms with all mice dying or moribund within 24 hours unlike similarly treated wild-type mice that recover within 24 hours

• donepezil-treated mice fail to recover normal body temperature unlike similarly treated wild-type mice

• (-)-huperzin A-treated mice exhibit protosis, salivation, and lacrimation with death occurring within 24 hours of treatment unlike similarly treated mice