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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Bchetm1Loc
targeted mutation 1, Oksana Lockridge
MGI:3723049
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Bchetm1Loc/Bchetm1Loc involves: 129S1/Sv MGI:3723137
ht2
Bchetm1Loc/Bche+ involves: 129S1/Sv MGI:3848447


Genotype
MGI:3723137
hm1
Allelic
Composition
Bchetm1Loc/Bchetm1Loc
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bchetm1Loc mutation (2 available); any Bche mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• donepezil-treated mice die within 3 hours unlike similarly treated controls
• (-)-huperzin A-treated mice die within 10 minutes unlike similarly treated controls

reproductive system
N
• mice are fertile

homeostasis/metabolism
• donepezil-treated mice die within 3 hours unlike similarly treated controls
• (-)-huperzin A-treated mice die within 10 minutes unlike similarly treated controls
• treatment with donepezil induces clonic, jerking convulsions and death within 3 hours unlike similarly treated wild-type mice that recover within 24 hours
• (-)-huperzin A-treated mice exhibit protosis, salivation, and lacrimation with death occurring within 10 minutes of treatment unlike similarly treated mice
• however, mice exhibit a normal reaction to CPO and echothiophate




Genotype
MGI:3848447
ht2
Allelic
Composition
Bchetm1Loc/Bche+
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bchetm1Loc mutation (2 available); any Bche mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• donepezil-treated mice die within 24 hours unlike similarly treated controls
• (-)-huperzin A-treated mice die within 24 hours unlike similarly treated controls

homeostasis/metabolism
• donepezil-treated mice die within 24 hours unlike similarly treated controls
• (-)-huperzin A-treated mice die within 24 hours unlike similarly treated controls
• treatment with donepezil induces intermediate symptoms with all mice dying or moribund within 24 hours unlike similarly treated wild-type mice that recover within 24 hours
• donepezil-treated mice fail to recover normal body temperature unlike similarly treated wild-type mice
• (-)-huperzin A-treated mice exhibit protosis, salivation, and lacrimation with death occurring within 24 hours of treatment unlike similarly treated mice





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory