All Phenotypes Tg(tetO-tetX,lacZ)1Gogo MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(tetO-tetX,lacZ)1Gogo
transgene insertion 1, Joseph Gogos
MGI:3723430

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)1Gogo/?	involves: 129	MGI:3723456
cx2	Or10a4^tm5(rtTA)Rax/Or10a4⁺ Tg(tetO-tetX,lacZ)1Gogo/?	involves: 129S1/Sv	MGI:3723463
cx3	Ngfr^tm1Jae/Ngfr^tm1Jae Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)1Gogo/?	involves: 129S4/SvJae * C57BL/6	MGI:3723454

Allelic Composition	Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)1Gogo/?
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omp^tm1(tTA)Gogo mutation (1 available); any Omp mutation (27 available)
Tg(tetO-tetX,lacZ)1Gogo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory nerve morphology ( J:124050 , J:124299 )

• following doxycycline treatment, synaptic release in olfactory sensory neurons is inhibited (J:124050)

• following doxycycline treatment, the number of terminal branches of olfactory nerves is modestly increased relative to in wild-type mice (J:124050)

• following doxycycline treatment, synaptic release in olfactory sensory neurons is inhibited (J:124299)

Allelic Composition	Or10a4^tm5(rtTA)Rax/Or10a4⁺ Tg(tetO-tetX,lacZ)1Gogo/?
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or10a4^tm5(rtTA)Rax mutation (0 available); any Or10a4 mutation (22 available)
Tg(tetO-tetX,lacZ)1Gogo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory nerve morphology ( J:124299 )

• following doxycycline treatment during gestation or post-weaning, synaptic release in Olfr17+ olfactory sensory neurons is inhibited

• following doxycycline treatment during gestation, targeting of Olfr17+ olfactory nerves fail to converge on the Olfr17+ glomeruli and the number of lacZ+ olfactory nerves decreases with time

• following doxycycline treatment post-weaning, Olfr17+ olfactory nerves migrate randomly within 2 days of induction and their numbers are reduced

Allelic Composition	Ngfr^tm1Jae/Ngfr^tm1Jae Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)1Gogo/?
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfr^tm1Jae mutation (2 available); any Ngfr mutation (33 available)
Omp^tm1(tTA)Gogo mutation (1 available); any Omp mutation (27 available)
Tg(tetO-tetX,lacZ)1Gogo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory nerve morphology ( J:124050 )

• the positive effect of global presynaptic inactinity on the total branch length is somewhat attenuated

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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