Phenotypes associated with this allele

• Allele Symbol: Tg(tetO-tetX,lacZ)2Gogo
• Allele Name: transgene insertion 2, Joseph Gogos
• Allele ID: MGI:3723433
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Bdnf^tm1(BDNF)Gogo/Bdnf^+ Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S/SvEv	MGI:3723437
cx2	Bdnf^tm2(BDNF)Gogo/Bdnf^+ Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S/SvEv	MGI:3723439
cx3	Bdnf^tm1Jae/Bdnf^+ Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S4/SvJae * C57BL/6	MGI:3723444
cx4	Ngfr^tm1Jae/Ngfr^tm1Jae Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S4/SvJae * C57BL/6	MGI:3723445
cx5	Ngfr^tm1Jae/Ngfr^+ Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S4/SvJae * C57BL/6	MGI:3723452
cx6	Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-tetX,lacZ)2Gogo/?	Not Specified	MGI:3723455

Genotype
MGI:3723437

cx1

• Allelic Composition: Bdnf^{tm1(BDNF)Gogo}/Bdnf⁺; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-tetX,lacZ)2Gogo/?
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:124050 )

N • following doxycycline treatment, terminal-arbor complexity and total length of olfactory nerve axons is normal

Genotype
MGI:3723439

cx2

• Allelic Composition: Bdnf^{tm2(BDNF)Gogo}/Bdnf⁺; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-tetX,lacZ)2Gogo/?
• Genetic Background: involves: 129S/SvEv

nervous system

abnormal olfactory nerve morphology ( J:124050 )

• following doxycycline treatment, terminal-arbor complexity at P6 is reduced similar to in Tg(tetO-tetX,lacZ)2Gogo Omp^tm1(tTA)Gogo mice

Genotype
MGI:3723444

cx3

• Allelic Composition: Bdnf^tm1Jae/Bdnf⁺; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-tetX,lacZ)2Gogo/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6

nervous system

nervous system phenotype ( J:124050 )

N • following doxycycline treatment, terminal-arbor complexity of olfactory nerves is normal

Genotype
MGI:3723445

cx4

• Allelic Composition: Ngfr^tm1Jae/Ngfr^tm1Jae; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-tetX,lacZ)2Gogo/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6

nervous system

abnormal olfactory nerve morphology ( J:124050 )

• following doxycycline treatment, terminal-arbor complexity of olfactory nerves is rescued with 7 branches per axon compared to 1.96+/-0.17 in Tg(tetO-tetX,lacZ)2Gogo Omp^tm1(tTA)Gogo mice and 6.6+/-0.19 in wild-type mice but branching length is not restored

Genotype
MGI:3723452

cx5

• Allelic Composition: Ngfr^tm1Jae/Ngfr⁺; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-tetX,lacZ)2Gogo/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6

nervous system

abnormal olfactory nerve morphology ( J:124050 )

• following doxycycline treatment, terminal-arbor complexity is partially rescued (4 branches per axon compared to 1.96+/-0.17 in Tg(tetO-tetX,lacZ)2Gogo Omp^tm1(tTA)Gogo mice and 6.6+/-0.19 in wild-type mice)

Genotype
MGI:3723455

cx6

• Allelic Composition: Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-tetX,lacZ)2Gogo/?
• Genetic Background: Not Specified

nervous system

abnormal olfactory nerve morphology ( J:124050 )

• following doxycycline treatment, synaptic release in olfactory sensory neurons is inhibited

• following doxycycline treatment, P6 mice exhibit a reduction in terminal-arbor complexity (1.96+/-0.17 branches per axon arbor compared to 6.6+/-0.19 in wild-type mice) and total length (153.29+/-13.16 um compared to 231.6+/-0.19 um in wild-type mice)

• following doxycycline treatment, large axonal varicosities are increased as are signs of degeneration

• however, normal branching can be reconstituted with the application of an NMDR inhibitor (MK-801)