All Phenotypes Tg(tetO-Kcnj2,lacZ)1Gogo MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(tetO-Kcnj2,lacZ)1Gogo
transgene insertion 1, Joseph Gogos
MGI:3723462

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-Kcnj2,lacZ)1Gogo/?	involves: 129 * C57BL/6 * CBA	MGI:3723464
cx2	Or4e5^tm2Rax/Or4e5⁺ Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-Kcnj2,lacZ)1Gogo/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3723466
cx3	Or10a4^tm6Rax/Or10a4^tm6Rax Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-Kcnj2,lacZ)1Gogo/?	involves: 129S1/Sv * C57BL/6 * CBA	MGI:3723465
cx4	Or10a4^tm5(rtTA)Rax/Or10a4⁺ Tg(tetO-Kcnj2,lacZ)1Gogo/?	involves: 129S1/Sv * C57BL/6 * CBA	MGI:3723467

Allelic Composition	Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-Kcnj2,lacZ)1Gogo/?
Genetic Background	involves: 129 * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omp^tm1(tTA)Gogo mutation (1 available); any Omp mutation (27 available)
Tg(tetO-Kcnj2,lacZ)1Gogo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory bulb morphology ( J:124299 )

• following doxycycline treatment, organization of the glomeruli in the dorsal part of the bulb remains disorganized, thinly innervated, necklace glomeruli are absent, and nerves that enter the bulb coalesce into a giant glomerulus-like structure

abnormal olfactory nerve morphology ( J:124299 )

• following doxycycline treatment, the spiking activity of olfactory nerves is inhibited

• following doxycycline treatment, the entry of the sensory neuron into the olfactory bulb is delayed

Allelic Composition	Or4e5^tm2Rax/Or4e5⁺ Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-Kcnj2,lacZ)1Gogo/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omp^tm1(tTA)Gogo mutation (1 available); any Omp mutation (27 available)
Or4e5^tm2Rax mutation (0 available); any Or4e5 mutation (20 available)
Tg(tetO-Kcnj2,lacZ)1Gogo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory nerve morphology ( J:124299 )

• following doxycycline treatment, at P1 and more profoundly at P21 Olfr17+ olfactory nerves are diffusely distributed and 75% of those that enter the olfactory bulb innervate two to three glomeruli in the ventral portion of the bulb

Allelic Composition	Or10a4^tm6Rax/Or10a4^tm6Rax Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-Kcnj2,lacZ)1Gogo/?
Genetic Background	involves: 129S1/Sv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omp^tm1(tTA)Gogo mutation (1 available); any Omp mutation (27 available)
Or10a4^tm6Rax mutation (0 available); any Or10a4 mutation (22 available)
Tg(tetO-Kcnj2,lacZ)1Gogo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory nerve morphology ( J:124299 )

• following doxycycline treatment, at P1 and more profoundly at P21 Olfr17+ olfactory nerves are diffusely distributed and those that enter the olfactory bulb sparsely innervate an average of 16 glomeruli in the ventral portion of the bulb

Allelic Composition	Or10a4^tm5(rtTA)Rax/Or10a4⁺ Tg(tetO-Kcnj2,lacZ)1Gogo/?
Genetic Background	involves: 129S1/Sv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or10a4^tm5(rtTA)Rax mutation (0 available); any Or10a4 mutation (22 available)
Tg(tetO-Kcnj2,lacZ)1Gogo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory nerve morphology ( J:124299 )

• following doxycycline treatment during gestation, Oflr17+ olfactory nerve cells call to enter the olfactory bulb with only a few fibers crossing the cribriform plate that do not converge to form a single glomerulus but innervate a broad region o the ventral portion of the bulb

• following doxycycline treatment during gestation, the number of Oflr17+ olfactory nerves is decreased by 5-fold at P21

• after 40 days of doxycycline, Olfr17+ olfactory nerves no longer converge on a Oflr17+ glomerulus and few nerves stain positive for lacZ

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