Phenotypes associated with this allele

• Allele Symbol: Tamalin^tm1.1Nak
• Allele Name: targeted mutation 1.1, Shigetada Nakanishi
• Allele ID: MGI:3723519
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tamalin^tm1.1Nak/Tamalin^tm1.1Nak	B6.129S-Tamalin^tm1.1Nak	MGI:3757984

Genotype
MGI:3757984

hm1

• Allelic Composition: Tamalin^tm1.1Nak/Tamalin^tm1.1Nak
• Genetic Background: B6.129S-Tamalin^tm1.1Nak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to morphine ( J:124994 )

• during the acute phase of morphine-induced hyperlocomotion, there is a reduced in distance traveled by mice compared to wild-type mice at 2.5 mg/kg and 5 mg/kg but not 10 mg/kg of morphine

• however, morphine antinociceptive tolerance and morphine withdrawal effects on mice are unaltered

impaired conditioned place preference behavior ( J:124994 )

• conditioned place preference is reduced at 3 mg/kg morphine

decreased chemically-elicited antinociception ( J:124994 )

• mice treated with 10mg/kg morphine and subjected to a hotplate test exhibit decreased analgesic response to morphine relative to wild-type mice during the first 40 minutes

• however, the duration of morphine's analgesic effect was unchanged (about 90 minutes) and there is no differences in morpholino maximal possible effect in a tail-flick test are observed

• the maximal possible effect of 10 mg/kg morphine is decreased relative to wild-type but unchanged at 20 mg/kg