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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Psmb10tm1Mgro
targeted mutation 1, Marcus Groettrup
MGI:3723600
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Psmb10tm1Mgro/Psmb10tm1Mgro involves: 129S2/SvPas * C57BL/6 MGI:3758657
ht2
 		Psmb10tm1Mgro/Psmb10Tub6 involves: 129S2/SvPas * C3HeB/FeJ MGI:6154976
cx3
 		Psmb10tm1Mgro/Psmb10tm1Mgro
Psmb9/Psmb8tm1Klr/Psmb9/Psmb8tm1Klr 		B6.129-Psmb10tm1Mgro Psmb9/Psmb8tm1Klr MGI:5563850
cx4
 		Psmb10tm1Mgro/Psmb10tm1Mgro
Psmb9/Psmb8tm1Klr/Psmb9/Psmb8tm1Klr 		B6.129-Psmb10tm1Mgro Psmb9/Psmb8tm1Klr MGI:5563851


Genotype
MGI:3758657
hm1
Allelic
Composition		 Psmb10tm1Mgro/Psmb10tm1Mgro
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb10tm1Mgro mutation (1 available); any Psmb10 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:125058 )
• cells fail to proliferate when transferred to a lymphocytic choriomeningitis virus infected wild-type mouse
decreased CD8-positive, alpha-beta T cell number ( J:125058 )
• 20% reduction in spleen
• however, the number of CD4+ cells is unaffected and no change is seen in CD4+ or CD8+ cell numbers in the thymus
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:125058 )
• reduction in the number of cells that bind to MHC tetramer loaded with a viral specific antigen
• reduction in the frequency of cells that respond to a viral specific antigen
abnormal cytotoxic T cell physiology ( J:125058 )
• reduction in interferon gamma production in response to some but not all antigens of the lymphocytic choriomeningitis virus

hematopoietic system
decreased T cell proliferation ( J:125058 )
• cells fail to proliferate when transferred to a lymphocytic choriomeningitis virus infected wild-type mouse
decreased CD8-positive, alpha-beta T cell number ( J:125058 )
• 20% reduction in spleen
• however, the number of CD4+ cells is unaffected and no change is seen in CD4+ or CD8+ cell numbers in the thymus
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:125058 )
• reduction in the number of cells that bind to MHC tetramer loaded with a viral specific antigen
• reduction in the frequency of cells that respond to a viral specific antigen
abnormal cytotoxic T cell physiology ( J:125058 )
• reduction in interferon gamma production in response to some but not all antigens of the lymphocytic choriomeningitis virus

cellular
decreased T cell proliferation ( J:125058 )
• cells fail to proliferate when transferred to a lymphocytic choriomeningitis virus infected wild-type mouse




Genotype
MGI:6154976
ht2
Allelic
Composition		 Psmb10tm1Mgro/Psmb10Tub6
Genetic
Background		 involves: 129S2/SvPas * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb10tm1Mgro mutation (1 available); any Psmb10 mutation (18 available)
Psmb10Tub6 mutation (1 available); any Psmb10 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system

hematopoietic system




Genotype
MGI:5563850
cx3
Allelic
Composition		 Psmb10tm1Mgro/Psmb10tm1Mgro
Psmb9/Psmb8tm1Klr/Psmb9/Psmb8tm1Klr
Genetic
Background		 B6.129-Psmb10tm1Mgro Psmb9/Psmb8tm1Klr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb10tm1Mgro mutation (1 available); any Psmb10 mutation (18 available)
Psmb9/Psmb8tm1Klr mutation (0 available); any Psmb9 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:180765 )
• approximately 50% fewer mature CD8+ T cells in the thymus and spleen
• however, overall spleen and thymus cellularities are similar to controls
abnormal B lymphocyte antigen presentation ( J:180765 )
• splenocytes have impaired presentation of an OVA epitope that requires cleavage but not of an epitope that does not require cleavage
abnormal dendritic cell antigen presentation ( J:180765 )
• presentation of multiple different types of antigens by dendritic cells in vitro is less able to support proliferation of T cells
abnormal antigen presentation via MHC class I ( J:180765 )
• impaired presentation of lymphochoriomeningitis virus epitopes to T cells in vivo
• however, presentation of MHC class II epitopes (GP61 and NP309) is similar to controls
decreased level of surface class I molecules ( J:180765 )
• level is about half that of controls
• levels are decreased on CD4+ and CD8+ T cells in the blood, spleen, lymph nodes and thymus, on lymph node B cells, on splenic macrophages, dendritic cells, and B220+ splenocytes

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:180765 )
• approximately 50% fewer mature CD8+ T cells in the thymus and spleen
• however, overall spleen and thymus cellularities are similar to controls
abnormal B lymphocyte antigen presentation ( J:180765 )
• splenocytes have impaired presentation of an OVA epitope that requires cleavage but not of an epitope that does not require cleavage




Genotype
MGI:5563851
cx4
Allelic
Composition		 Psmb10tm1Mgro/Psmb10tm1Mgro
Psmb9/Psmb8tm1Klr/Psmb9/Psmb8tm1Klr
Genetic
Background		 B6.129-Psmb10tm1Mgro Psmb9/Psmb8tm1Klr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb10tm1Mgro mutation (1 available); any Psmb10 mutation (18 available)
Psmb9/Psmb8tm1Klr mutation (0 available); any Psmb8 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:180765 )
• approximately 50% fewer mature CD8+ T cells in the thymus and spleen
• however, overall spleen and thymus cellularities are similar to controls
abnormal B lymphocyte antigen presentation ( J:180765 )
• splenocytes have impaired presentation of an OVA epitope that requires cleavage but not of an epitope that does not require cleavage
abnormal dendritic cell antigen presentation ( J:180765 )
• presentation of multiple different types of antigens by dendritic cells in vitro is less able to support proliferation of T cells
abnormal antigen presentation via MHC class I ( J:180765 )
• impaired presentation of lymphochoriomeningitis virus epitopes to T cells in vivo
• however, presentation of MHC class II epitopes (GP61 and NP309) is similar to controls
decreased level of surface class I molecules ( J:180765 )
• level is about half that of controls
• levels are decreased on CD4+ and CD8+ T cells in the blood, spleen, lymph nodes and thymus, on lymph node B cells, on splenic macrophages, dendritic cells, and B220+ splenocytes

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:180765 )
• approximately 50% fewer mature CD8+ T cells in the thymus and spleen
• however, overall spleen and thymus cellularities are similar to controls
abnormal B lymphocyte antigen presentation ( J:180765 )
• splenocytes have impaired presentation of an OVA epitope that requires cleavage but not of an epitope that does not require cleavage




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory