Phenotypes associated with this allele

• Allele Symbol: Timd2^{tm1(GAL4)Pdre}
• Allele Name: targeted mutation 1, Paul D Rennert
• Allele ID: MGI:3723608
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Timd2^tm1(GAL4)Pdre/Timd2^tm1(GAL4)Pdre	C.129S4-Timd2^tm1(GAL4)Pdre	MGI:3757608

Genotype
MGI:3757608

hm1

• Allelic Composition: Timd2^{tm1(GAL4)Pdre}/Timd2^{tm1(GAL4)Pdre}
• Genetic Background: C.129S4-Timd2^{tm1(GAL4)Pdre}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased eosinophil cell number ( J:125054 )

• following sensitization and challenge with ovalbumin, bronchial lavage fluid eosinophil numbers are increased

increased lymphocyte cell number ( J:125054 )

• following sensitization and challenge with ovalbumin, bronchial lavage fluid lymphocyte numbers are increased

increased interferon-gamma secretion ( J:125054 )

• T cells from keyhole limpet hemocyanin (KLH) treated T cells restimulated in culture with KLH produce increased amounts of interferon-gamma

• sensitized lymph node cells that were rechallenge with ovalbumin ex vivo produce higher levels of interferon-gamma than wild-type cells

abnormal interleukin secretion ( J:125054 )

• T cells from keyhole limpet hemocyanin (KLH) treated T cells restimulated in culture with KLH produce increased amounts of IL-4, IL-5 , IL-6 and IL-10

• sensitized lymph node cells that were rechallenge with ovalbumin ex vivo produce higher levels of IL-5, IL-10, and IL-13 (8- to 12-fold) and moderately higher levels of IL-4 and IL-6 compared to wild-type cells

increased tumor necrosis factor secretion ( J:125054 )

• sensitized lymph node cells that were rechallenge with ovalbumin ex vivo produce twice as much TNF-alpha as wild-type cells

abnormal inflammatory response ( J:125054 )

• following sensitization and challenge with ovalbumin, interstitial mononuclear cell infiltrates in the lungs are larger in size than in wild-type mice and staining for mucus is more extensive and more intense

• sensitized lymph node cells that were rechallenge with ovalbumin ex vivo exhibit increased proliferation compared to wild-type cells

hematopoietic system

increased eosinophil cell number ( J:125054 )

• following sensitization and challenge with ovalbumin, bronchial lavage fluid eosinophil numbers are increased

increased lymphocyte cell number ( J:125054 )

• following sensitization and challenge with ovalbumin, bronchial lavage fluid lymphocyte numbers are increased