All Phenotypes Hoxa5<tm1.1Ljea> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxa5^tm1.1Ljea
targeted mutation 1.1, Lucie Jeannotte
MGI:3723622

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxa5^tm1.1Ljea/Hoxa5^tm1.1Ljea	involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J * SJL	MGI:3723626
cn2	Hoxa5^tm1.1Ljea/Hoxa5^tm1.1Ljea Tg(Sftpc-cre)1Blh/0	involves: 129 * C57BL/6J * DBA/2 * SJL	MGI:6404241
cn3	Hoxa5^tm1.1Ljea/Hoxa5⁺ Tg(Sftpc-cre)1Blh/0	involves: 129 * C57BL/6J * DBA/2 * SJL	MGI:6404242
cn4	Hoxa5^tm1.1Ljea/Hoxa5^tm1.1Ljea Tg(Hoxa5-cre)447BLjea/0	involves: 129/Sv * C57BL/6 * CBA * SJL	MGI:5561200
cn5	Hoxa5^tm1.1Ljea/Hoxa5^tm1.1Ljea Tg(Hoxa5-cre)444CLjea/0	involves: 129/Sv * C57BL/6 * CBA * SJL	MGI:5561199

Allelic Composition	Hoxa5^tm1.1Ljea/Hoxa5^tm1.1Ljea
Genetic Background	involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa5^tm1.1Ljea mutation (0 available); any Hoxa5 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:125040 )

• mice are viable and fertile

Allelic Composition	Hoxa5^tm1.1Ljea/Hoxa5^tm1.1Ljea Tg(Sftpc-cre)1Blh/0
Genetic Background	involves: 129 * C57BL/6J * DBA/2 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa5^tm1.1Ljea mutation (0 available); any Hoxa5 mutation (27 available)
Tg(Sftpc-cre)1Blh mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

lung cyst ( J:170336 )

• as in mice with only Tg(Sftpc-cre)1Blh

abnormal pulmonary alveolar sac morphology ( J:170336 )

• distended alveoli at the periphery of lobes at day 30 as in mice with only Tg(Sftpc-cre)1Blh

growth/size/body

lung cyst ( J:170336 )

• as in mice with only Tg(Sftpc-cre)1Blh

Allelic Composition	Hoxa5^tm1.1Ljea/Hoxa5⁺ Tg(Sftpc-cre)1Blh/0
Genetic Background	involves: 129 * C57BL/6J * DBA/2 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa5^tm1.1Ljea mutation (0 available); any Hoxa5 mutation (27 available)
Tg(Sftpc-cre)1Blh mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

lung cyst ( J:170336 )

• as in mice with only Tg(Sftpc-cre)1Blh

abnormal pulmonary alveolar sac morphology ( J:170336 )

• distended alveoli at the periphery of lobes at day 30 as in mice with only Tg(Sftpc-cre)1Blh

growth/size/body

lung cyst ( J:170336 )

• as in mice with only Tg(Sftpc-cre)1Blh

Allelic Composition	Hoxa5^tm1.1Ljea/Hoxa5^tm1.1Ljea Tg(Hoxa5-cre)447BLjea/0
Genetic Background	involves: 129/Sv * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa5^tm1.1Ljea mutation (0 available); any Hoxa5 mutation (27 available)
Tg(Hoxa5-cre)447BLjea mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:207917 )

• about 42% of the pups with the conditional knockout genotype are found dead at birth

• normal Mendelian ratios are found at E18.5

respiratory system

abnormal lung development ( J:207917 )

• at E18.5, lungs display collapsed morphology similar to that observed for Hoxa5^tm1Rob homozygotes

abnormal pulmonary alveolus morphology ( J:207917 )

• enlargement of alveolar spaces is observed in surviving mice at P30, similar to that observed in Hoxa5^-/- animals

abnormal trachea morphology ( J:207917 )

• severe disorganization of the trachea is observed in E18.5 skeletons

respiratory distress ( J:207917 )

• pups display respiratory distress at birth at birth

skeleton

abnormal xiphoid process morphology ( J:207917 )

• process is misshapen at E18.5

increased rib number ( J:207917 )

• extra ribs on cervical vertebra 7 (C7) are observed at E18.5

abnormal cervical vertebrae morphology ( J:207917 )

• absent or shorter tuberculum anterior are observed on C6 at E18.5

Allelic Composition	Hoxa5^tm1.1Ljea/Hoxa5^tm1.1Ljea Tg(Hoxa5-cre)444CLjea/0
Genetic Background	involves: 129/Sv * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa5^tm1.1Ljea mutation (0 available); any Hoxa5 mutation (27 available)
Tg(Hoxa5-cre)444CLjea mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:207917 )

N	• no mortality is observed; all expected genotypes are found at normal Mendelian ratios

respiratory system

respiratory system phenotype ( J:207917 )

N	• trachea is normal at E18.5

skeleton

abnormal xiphoid process morphology ( J:207917 )

• at the caudal extremity of the sternum an abnormal xiphoid process is observed at E18.5

abnormal cervical vertebrae morphology ( J:207917 )

• loss of tuberculum anterior on the sixth cervical vertebra (C6) is observed at E18.5

• ectopic ribs are not observed on C7

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 08/02/2024 MGI 6.24