All Phenotypes Hoxa5<tm1.1Ljea> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxa5^tm1.1Ljea
targeted mutation 1.1, Lucie Jeannotte
MGI:3723622

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxa5^tm1.1Ljea/Hoxa5^tm1.1Ljea	involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J * SJL	MGI:3723626
cn2	Hoxa5^tm1.1Ljea/Hoxa5^tm1.1Ljea Tg(Sftpc-cre)1Blh/0	involves: 129 * C57BL/6J * DBA/2 * SJL	MGI:6404241
cn3	Hoxa5^tm1.1Ljea/Hoxa5⁺ Tg(Sftpc-cre)1Blh/0	involves: 129 * C57BL/6J * DBA/2 * SJL	MGI:6404242
cn4	Hoxa5^tm1.1Ljea/Hoxa5^tm1.1Ljea Tg(Hoxa5-cre)447BLjea/0	involves: 129/Sv * C57BL/6 * CBA * SJL	MGI:5561200
cn5	Hoxa5^tm1.1Ljea/Hoxa5^tm1.1Ljea Tg(Hoxa5-cre)444CLjea/0	involves: 129/Sv * C57BL/6 * CBA * SJL	MGI:5561199

Allelic Composition	Hoxa5^tm1.1Ljea/Hoxa5^tm1.1Ljea
Genetic Background	involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa5^tm1.1Ljea mutation (1 available); any Hoxa5 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:125040 )

• mice are viable and fertile

Allelic Composition	Hoxa5^tm1.1Ljea/Hoxa5^tm1.1Ljea Tg(Sftpc-cre)1Blh/0
Genetic Background	involves: 129 * C57BL/6J * DBA/2 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa5^tm1.1Ljea mutation (1 available); any Hoxa5 mutation (28 available)
Tg(Sftpc-cre)1Blh mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

lung cyst ( J:170336 )

• as in mice with only Tg(Sftpc-cre)1Blh

abnormal pulmonary alveolar sac morphology ( J:170336 )

• distended alveoli at the periphery of lobes at day 30 as in mice with only Tg(Sftpc-cre)1Blh

growth/size/body

lung cyst ( J:170336 )

• as in mice with only Tg(Sftpc-cre)1Blh

Allelic Composition	Hoxa5^tm1.1Ljea/Hoxa5⁺ Tg(Sftpc-cre)1Blh/0
Genetic Background	involves: 129 * C57BL/6J * DBA/2 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa5^tm1.1Ljea mutation (1 available); any Hoxa5 mutation (28 available)
Tg(Sftpc-cre)1Blh mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

lung cyst ( J:170336 )

• as in mice with only Tg(Sftpc-cre)1Blh

abnormal pulmonary alveolar sac morphology ( J:170336 )

• distended alveoli at the periphery of lobes at day 30 as in mice with only Tg(Sftpc-cre)1Blh

growth/size/body

lung cyst ( J:170336 )

• as in mice with only Tg(Sftpc-cre)1Blh

Allelic Composition	Hoxa5^tm1.1Ljea/Hoxa5^tm1.1Ljea Tg(Hoxa5-cre)447BLjea/0
Genetic Background	involves: 129/Sv * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa5^tm1.1Ljea mutation (1 available); any Hoxa5 mutation (28 available)
Tg(Hoxa5-cre)447BLjea mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:207917 )

• about 42% of the pups with the conditional knockout genotype are found dead at birth

• normal Mendelian ratios are found at E18.5

respiratory system

abnormal lung development ( J:207917 )

• at E18.5, lungs display collapsed morphology similar to that observed for Hoxa5^tm1Rob homozygotes

abnormal pulmonary alveolus morphology ( J:207917 )

• enlargement of alveolar spaces is observed in surviving mice at P30, similar to that observed in Hoxa5^-/- animals

abnormal trachea morphology ( J:207917 )

• severe disorganization of the trachea is observed in E18.5 skeletons

respiratory distress ( J:207917 )

• pups display respiratory distress at birth at birth

skeleton

abnormal xiphoid process morphology ( J:207917 )

• process is misshapen at E18.5

increased rib number ( J:207917 )

• extra ribs on cervical vertebra 7 (C7) are observed at E18.5

abnormal cervical vertebrae morphology ( J:207917 )

• absent or shorter tuberculum anterior are observed on C6 at E18.5

Allelic Composition	Hoxa5^tm1.1Ljea/Hoxa5^tm1.1Ljea Tg(Hoxa5-cre)444CLjea/0
Genetic Background	involves: 129/Sv * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa5^tm1.1Ljea mutation (1 available); any Hoxa5 mutation (28 available)
Tg(Hoxa5-cre)444CLjea mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:207917 )

N	• no mortality is observed; all expected genotypes are found at normal Mendelian ratios

respiratory system

respiratory system phenotype ( J:207917 )

N	• trachea is normal at E18.5

skeleton

abnormal xiphoid process morphology ( J:207917 )

• at the caudal extremity of the sternum an abnormal xiphoid process is observed at E18.5

abnormal cervical vertebrae morphology ( J:207917 )

• loss of tuberculum anterior on the sixth cervical vertebra (C6) is observed at E18.5

• ectopic ribs are not observed on C7

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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