Phenotypes associated with this allele

• Allele Symbol: Hoxa5^tm1.2Ljea
• Allele Name: targeted mutation 1.2, Lucie Jeannotte
• Allele ID: MGI:3723624
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxa5^tm1.2Ljea/Hoxa5^tm1.2Ljea	involves: 129/Sv * C57BL/6 * CBA * SJL	MGI:3723627

Genotype
MGI:3723627

hm1

• Allelic Composition: Hoxa5^tm1.2Ljea/Hoxa5^tm1.2Ljea
• Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:125040 )

• mortality occurs at birth with fewer than expected mice surviving to weaning

• however, surviving mice are viable, fertile and present no phenotypic abnormalities

respiratory system

abnormal pulmonary alveolus morphology ( J:125040 )

• alveolar architecture is simplified

• in adult mice, lungs have an emphysema-like phenotype with areas depleted of alveoli

atelectasis ( J:125040 )

• at E18.5, mice present with collapsed lungs

emphysema ( J:125040 )

• in adult mice, lungs have an emphysema-like phenotype with areas depleted of alveoli

increased respiratory mucosa goblet cell number ( J:125040 )

• the number of mucus-producing cells in the lungs is increased

abnormal tracheal cartilage morphology ( J:125040 )

• all mice have abnormal trachea with fusion of the first tracheal rings to the cricoid, an abnormal banding pattern of the rings and a reduced dorsal extension of the cartilage along the trachea

cricoid and tracheal cartilage fusion ( J:125040 )

• fusion of the first tracheal rings to the cricoid

skeleton

abnormal tracheal cartilage morphology ( J:125040 )

• all mice have abnormal trachea with fusion of the first tracheal rings to the cricoid, an abnormal banding pattern of the rings and a reduced dorsal extension of the cartilage along the trachea

cricoid and tracheal cartilage fusion ( J:125040 )

• fusion of the first tracheal rings to the cricoid

abnormal cervical vertebrae morphology ( J:125040 )

• at E18.5, the tuberculum anterior on C6 is absent in all mice bilaterally

• at E18.5, ribs are present on C7 bilaterally in 8 of 10 mice and unilaterally in 2 of 10 mice compared to wild-type mice in which ribs are absent bilaterally in nearly all mice

• at E18.5, ectopic dorsal processes are present on C4, C5 and T1 in all mice as opposed to 50% of wild-type mice

• however, mice retain the dorsal process on T2 unlike in other Hoxa5 null mice