Phenotypes associated with this allele

• Allele Symbol: Aqp7^tm1Chan
• Allele Name: targeted mutation 1, Lawrence Chan
• Allele ID: MGI:3723644
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aqp7^tm1Chan/Aqp7^tm1Chan	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3723645

Genotype
MGI:3723645

hm1

• Allelic Composition: Aqp7^tm1Chan/Aqp7^tm1Chan
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:125011 )

• the number of somatostatin producing islet cells is normal

• islet cell proliferation and apoptosis rates are decreased

decreased PP cell number ( J:125011 )

• the number of pancreatic polypeptide producing islet cells is reduced

decreased pancreatic alpha cell number ( J:125011 )

• the number of glucagon producing islet cells is reduced

decreased pancreatic beta cell number ( J:125011 )

• the number of insulin-positive cells is reduced by half relative to wild-type mice

small pancreatic islets ( J:125011 )

• insulin-positive cell clusters are smaller

increased insulin secretion ( J:125011 )

• insulin secretion from pancreatic islet cells is increased in low-glucose medium and in response to elevated glucose concentration compared to in wild-type mice

• however, insulin tolerance is normal

homeostasis/metabolism

increased insulin secretion ( J:125011 )

• insulin secretion from pancreatic islet cells is increased in low-glucose medium and in response to elevated glucose concentration compared to in wild-type mice

• however, insulin tolerance is normal

increased circulating insulin level ( J:125011 )

• increased insulin secretion from pancreatic islet cells is associated with elevated fasting plasma insulin

• insulin plasma levels for males (1053.8+/-288.1 pg/mL) and females (711.6+/-114.0 pg/mL) are increased relative to in wild-type mice (535.8+/-213.1 pg/mL and 379+/-193.6 pg/mL, respectively)

increased glycerol level ( J:125011 )

• the level of glycerol in the pancreatic islets is increased greater than 2-fold

• under basal conditions the release of glycerol from pancreatic islet cells is reduced compared to in wild-type mice

• forskolin-induced glycerol release from pancreatic islet cells is abolished

cellular

increased cellular glucose import ( J:125011 )

• islet cells glucose uptake is increased under basal and high-glucose conditions relative to in wild-type mice

adipose tissue

adipose tissue phenotype ( J:125011 )

N • mice have normal fat pad masses