Phenotypes associated with this allele

• Allele Symbol: Tg(Th-SNCA*)1702Yosh
• Allele Name: transgene insertion 1702, Makoto Yoshimoto
• Allele ID: MGI:3757756
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Th-SNCA*)1702Yosh/Tg(Th-SNCA*)1702Yosh	involves: C3H * C57BL/6J	MGI:3757844
tg2	Tg(Th-SNCA*)1702Yosh/0	involves: C3H * C57BL/6J	MGI:3757843

Genotype
MGI:3757844

tg1

• Allelic Composition: Tg(Th-SNCA*)1702Yosh/Tg(Th-SNCA*)1702Yosh
• Genetic Background: involves: C3H * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:125149 )

• newborn mice do not survive past postnatal day one

nervous system

loss of dopaminergic neurons ( J:125149 )

• after E11.5, expression level of tyrosine hydroxylase brain is significantly lower relative to non-transgenic mice indicating loss of dopaminergic neurons during development

respiratory system

apnea ( J:125149 )

• homozygotes delivered by Caesarean section at 19 days post-coitum have an higher incidence of apneas after delivery compared to heterozygotes or wild-type littermates

Genotype
MGI:3757843

tg2

• Allelic Composition: Tg(Th-SNCA*)1702Yosh/0
• Genetic Background: involves: C3H * C57BL/6J

behavior/neurological

bradykinesia ( J:125149 )

• both diurnal and nocturnal spontaneous locomotor activities are reduced compared to controls; significant recovery is seen upon injection of 150 mg/kg of dopamine precursor L-DOPA, whereas this dose does not affect non-transgenic controls

nervous system

decreased dopaminergic neuron number ( J:125149 )

• ~45% of dopaminergic neurons in the substantia nigra pars compacta, SNc, with the lateral part particularly affected, compared to non-transgenic littermates at 8 weeks of age or in transgnic mice expressing full-length mutant alpha-synuclein; considerable loss of neuronal cell bodies in the SNc region is observed

• no loss is observed in the ventral tegmental area, VTA

• loss is stable and no increased loss is seen to 52 weeks of age

abnormal neurite morphology ( J:125149 )

• tyrosine hydroxylase-positive, TH+, neurites are markedly impaired in striatum of mutants

homeostasis/metabolism

decreased dopamine level ( J:125149 )

• striatal dopamine, DA, and the dopamine metabolite homovanillic acid, HVA are reduced to ~49% and ~52% relative to controls; content of another metabolite, DOPAC, is reduced similarly in 8 week old mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 1		DOID:0060367	OMIM:168601	J:125149