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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dbx1tm1(DTA)Apie
targeted mutation 1, Alessandra Pierani
MGI:3757953
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Dbx1tm1(DTA)Apie/Dbx1+
Pax7tm1(cre)Mrc/Pax7+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4837354
cn2
Dbx1tm1(DTA)Apie/Dbx1+
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:3770261


Genotype
MGI:4837354
cn1
Allelic
Composition
Dbx1tm1(DTA)Apie/Dbx1+
Pax7tm1(cre)Mrc/Pax7+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbx1tm1(DTA)Apie mutation (1 available); any Dbx1 mutation (25 available)
Pax7tm1(cre)Mrc mutation (2 available); any Pax7 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• at E15.5, rhythmic activity in the pre-Botzinger complex is preserved




Genotype
MGI:3770261
cn2
Allelic
Composition
Dbx1tm1(DTA)Apie/Dbx1+
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbx1tm1(DTA)Apie mutation (1 available); any Dbx1 mutation (25 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• differences in cortical cytoarchitecture were observed in both rostral and caudal level
• the mutant cortex did not show a typical Reeler phenotype
• strong decrease to a complete loss of Reelin expressing cells in the rostrocaudal axis of the telencephalic vesicles and of the olfactory bulb at E11.5 and E12.5
• no significant differences in Reelin expression in cortex of the wild-type and mutant at E14.5





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last database update
09/03/2024
MGI 6.24
The Jackson Laboratory