cardiovascular system
• 47% of E15.5 fetuses show great vessel defects
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Allele Symbol Allele Name Allele ID |
Tbx1tm6(cre)Bld targeted mutation 6, Antonio Baldini MGI:3757964 |
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Summary |
10 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• 47% of E15.5 fetuses show great vessel defects
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• in all mice
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• in all mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice exhibit normal heart development at E14.5
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N |
• mice do not exhibit any morphological defects in the inner ear
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
Heart development defects in Tbx1tm6(cre)Bld/Tbx1+ Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sortm1(Tbx1/GFP)Bem mice
• no mice are present at P10
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• in 2 of 5 mice
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• in 3 of 5 mice
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• in all mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• collapse of the membranes of the vestibular compartments
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• cristae degeneration
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• abnormal lymphatic vessels fail to extend into distal mesentery unlike in wild-type mice
• between E15.5 and E16.5, lymphatic vessels are almost completely lost unlike in wild-type mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
Gt(ROSA)26Sortm1(Tbx1/GFP)Bem can patially rescue heart phenotypes in Tbx1tm6(cre)Bld/Tbx1tm1Bld mice
• in 5 of 6 mice
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• in 1 of 6 mice
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• in 5 of 6 mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
Failure of inner ear morphogenesis in Tbx1tm1Bld/Tbx1tm1Bld mice at E14.5 and partial rescue of inner ear morphogenesis in Tbx1tm6(cre)Bld/Tbx1tm1Bld Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/ Gt(ROSA)26Sor+ mice
N |
• recovery of the anterior and posterior semicircular canals compared with null mice
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• partial rescue with null mice
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• partial rescue with null mice
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• in half of mice
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• in all mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• at E15.5, hearts show no great vessel defects; outflow tract septation is largely normal and the atrial septum and atrioventricular valves are intact
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• 52% of E15.5 fetuses show great vessel defects
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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