Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Myh6*/tetO-GCaMP2)1Mik transgene insertion 1, Michael I Kotlikoff MGI:3757978 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 43% of E12.5 dark-like homozygotes display abnormal calcium transients such as early after-depolarizations and interval irregularities, and those hearts that have these abnormalities also have thickened ventricular walls whereas those not displaying irregularities in calcium handling appeared normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• cardiomegaly develops in adults in the absence of dox (unregulated expression of GCaMP2); double transgenics maintained on dox have normal heart size
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• cardiomegaly develops in adults in the absence of dox (unregulated expression of GCaMP2); double transgenics maintained on dox have normal heart size
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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