All Phenotypes Tg(SV40-NRAS*G12D)1Sco MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Mapkapk5^tm1Pqs/Mapkapk5^tm1Pqs Tg(SV40-NRAS*G12D)1Sco/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3757991
cx2	Mapkapk5^tm1Pqs/Mapkapk5⁺ Tg(SV40-NRAS*G12D)1Sco/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3757992
tg3	Tg(SV40-NRAS*G12D)1Sco/?	Not Specified	MGI:3765442

Allelic Composition	Mapkapk5^tm1Pqs/Mapkapk5^tm1Pqs Tg(SV40-NRAS*G12D)1Sco/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapkapk5^tm1Pqs mutation (0 available); any Mapkapk5 mutation (30 available)
Tg(SV40-NRAS*G12D)1Sco mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased lymphoma incidence ( J:117893 )

• lymphomagenesis is enhanced in the few surviving mice relative to in Tg(SV40-NRAS*G12D)1Sco mice

Allelic Composition	Mapkapk5^tm1Pqs/Mapkapk5⁺ Tg(SV40-NRAS*G12D)1Sco/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapkapk5^tm1Pqs mutation (0 available); any Mapkapk5 mutation (30 available)
Tg(SV40-NRAS*G12D)1Sco mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased lymphoma incidence ( J:117893 )

• lymphomagenesis is enhanced relative to in Tg(SV40-NRAS*G12D)1Sco mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased T cell derived lymphoma incidence ( J:125150 )

• two female primary transgenic mice develop T cell lymphomas, one at 10 weeks and the other at 17

• during the first 6 months of life, 9 females and 3 males develop thymic T cell lymphomas while 10 females and 3 males develop thymic T cell lymphomas and reticulum cell sarcoma type A together

increased sarcoma incidence ( J:125150 )

• during the first 6 months of life, 10 females and 17 males develop reticulum cell sarcoma type A while 10 females and 3 males develop thymic T cell lymphomas and reticulum cell sarcoma type A together

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:125150 )

• two female primary transgenic mice develop T cell lymphomas, one at 10 weeks and the other at 17

• during the first 6 months of life, 9 females and 3 males develop thymic T cell lymphomas while 10 females and 3 males develop thymic T cell lymphomas and reticulum cell sarcoma type A together

hematopoietic system

increased T cell derived lymphoma incidence ( J:125150 )

• two female primary transgenic mice develop T cell lymphomas, one at 10 weeks and the other at 17

• during the first 6 months of life, 9 females and 3 males develop thymic T cell lymphomas while 10 females and 3 males develop thymic T cell lymphomas and reticulum cell sarcoma type A together

immune system

increased T cell derived lymphoma incidence ( J:125150 )

• two female primary transgenic mice develop T cell lymphomas, one at 10 weeks and the other at 17

• during the first 6 months of life, 9 females and 3 males develop thymic T cell lymphomas while 10 females and 3 males develop thymic T cell lymphomas and reticulum cell sarcoma type A together

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