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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(SV40-NRAS*G12D)1Sco
transgene insertion 1, Suzanne Cory
MGI:3757990
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Mapkapk5tm1Pqs/Mapkapk5tm1Pqs
Tg(SV40-NRAS*G12D)1Sco/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3757991
cx2
Mapkapk5tm1Pqs/Mapkapk5+
Tg(SV40-NRAS*G12D)1Sco/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3757992
tg3
Tg(SV40-NRAS*G12D)1Sco/? Not Specified MGI:3765442


Genotype
MGI:3757991
cx1
Allelic
Composition
Mapkapk5tm1Pqs/Mapkapk5tm1Pqs
Tg(SV40-NRAS*G12D)1Sco/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapkapk5tm1Pqs mutation (0 available); any Mapkapk5 mutation (30 available)
Tg(SV40-NRAS*G12D)1Sco mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• lymphomagenesis is enhanced in the few surviving mice relative to in Tg(SV40-NRAS*G12D)1Sco mice




Genotype
MGI:3757992
cx2
Allelic
Composition
Mapkapk5tm1Pqs/Mapkapk5+
Tg(SV40-NRAS*G12D)1Sco/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapkapk5tm1Pqs mutation (0 available); any Mapkapk5 mutation (30 available)
Tg(SV40-NRAS*G12D)1Sco mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• lymphomagenesis is enhanced relative to in Tg(SV40-NRAS*G12D)1Sco mice




Genotype
MGI:3765442
tg3
Allelic
Composition
Tg(SV40-NRAS*G12D)1Sco/?
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• two female primary transgenic mice develop T cell lymphomas, one at 10 weeks and the other at 17
• during the first 6 months of life, 9 females and 3 males develop thymic T cell lymphomas while 10 females and 3 males develop thymic T cell lymphomas and reticulum cell sarcoma type A together
• during the first 6 months of life, 10 females and 17 males develop reticulum cell sarcoma type A while 10 females and 3 males develop thymic T cell lymphomas and reticulum cell sarcoma type A together

endocrine/exocrine glands
• two female primary transgenic mice develop T cell lymphomas, one at 10 weeks and the other at 17
• during the first 6 months of life, 9 females and 3 males develop thymic T cell lymphomas while 10 females and 3 males develop thymic T cell lymphomas and reticulum cell sarcoma type A together





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last database update
08/21/2024
MGI 6.24
The Jackson Laboratory