Phenotypes associated with this allele

• Allele Symbol: Taf4^tm1Idvd
• Allele Name: targeted mutation 1, Irwin Davidson
• Allele ID: MGI:3758058
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Taf4^tm1Idvd/Taf4^tm1Idvd Tg(KRT14-cre/ERT2)1Ipc/0	involves: C57BL/6 * SJL	MGI:3758083
cn2	Taf4^tm1Idvd/Taf4^tm1Idvd Tg(KRT14-cre)1Ipc/0	Not Specified	MGI:3758082

Genotype
MGI:3758083

cn1

• Allelic Composition: Taf4^tm1Idvd/Taf4^tm1Idvd; Tg(KRT14-cre/ERT2)1Ipc/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired skin barrier function ( J:124111 )

• increased transepidermal water loss

increased incidence of tumors by chemical induction ( J:124111 )

• more sensitive to tumor induction using DMBA and TPA

limbs/digits/tail

abnormal tail morphology ( J:124111 )

• hyperkeratinisation leading to drying

kinked tail ( J:124111 )

• resulting from hyperkeratinisation

• occasionally results in breakage

neoplasm

increased incidence of tumors by chemical induction ( J:124111 )

• more sensitive to tumor induction using DMBA and TPA

increased malignant tumor incidence ( J:124111 )

• large melanocyte tumors are found

• composed of densely packed melanocytes

• penetrate deeply into the dermis and invading the underlying muscle

• invasive melanocytes are also found in lymph nodes

increased squamous cell carcinoma incidence ( J:124111 )

• increased numbers of induced squamous cell carcinomas

immune system

chronic inflammation ( J:124111 )

• of the foot pads

integument

increased keratinocyte proliferation ( J:124111 )

• large numbers of suprabasal keratinocytes

• form 4-6 layers rather than the normal 1-2 layers

impaired skin barrier function ( J:124111 )

• increased transepidermal water loss

abnormal coat/ hair morphology ( J:124111 )

sparse hair ( J:124111 )

• uniform sparse coat results from the reduced density of hair regrowth

abnormal hair shaft morphology ( J:124111 )

• hair shafts are shorter and penetrate less deeply into the dermis

• poorly defined morphology

abnormal hair cycle ( J:124111 )

• hair fails to grow back after experimental depilation of the entire coat

• failure of hair follicles to enter anagen stage

abnormal skin morphology ( J:124111 )

epidermal hyperplasia ( J:124111 )

dry skin ( J:124111 )

• dry crinkly appearance with weak scaling except on the foot pads

scaly skin ( J:124111 )

• extensive scaling only on the foot pads which show inflammation as well

abnormal skin condition ( J:124111 )

dermal cyst ( J:124111 )

• many utriculi and closed dermal cysts form

cellular

increased keratinocyte proliferation ( J:124111 )

• large numbers of suprabasal keratinocytes

• form 4-6 layers rather than the normal 1-2 layers

growth/size/body

dermal cyst ( J:124111 )

• many utriculi and closed dermal cysts form

Genotype
MGI:3758082

cn2

• Allelic Composition: Taf4^tm1Idvd/Taf4^tm1Idvd; Tg(KRT14-cre)1Ipc/0
• Genetic Background: Not Specified

mortality/aging

neonatal lethality, complete penetrance ( J:124111 )

• death occurs shortly after birth

• no viable homozygotes are born

growth/size/body

weight loss ( J:124111 )

• size is normal at birth

• rapid and significant weight loss due to loss of water immediately after birth

• probably a significant factor in neonatal death

homeostasis/metabolism

impaired skin barrier function ( J:124111 )

• defective skin barrier function

• increased skin permeability, 10 fold increase in water loss

integument

impaired skin barrier function ( J:124111 )

• defective skin barrier function

• increased skin permeability, 10 fold increase in water loss

translucent skin ( J:124111 )

• embryos with shiny transparent skin at E18.5

thin skin ( J:124111 )

• very thin skin with reduced surface keratin