Analysis Tools
mortality/aging
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• less than half of the expected number of mice are born
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adipose tissue
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• at 5 to 6 weeks, male mice total fat pad mass is deduced to 35% of that in wild-type mice
• at 7 to 9 weeks, total fat pad mass is reduced to 66% of that in wild-type mice
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• apoptosis levels in white adipose tissue is increased relative to in wild-type mice
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• apoptosis levels in white adipose tissue is increased relative to in wild-type mice
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• mice have smaller white fat pads than wild-type mice
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homeostasis/metabolism
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• on a high fat diet, mice are resistant to diet-induced obesity despite increased energy intake in male mice
• the relative mass gained per amount of food consumed by male mice is decreased to 40% of that in wild-type male mice and in female mice it is decreased to 70% of that in wild-type female mice
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• plasma cholesterol level is reduced in male mice (60%)
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• plasma triglyceride levels are reduced in male (55%) and female (45%) mice compared to wild-type mice
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growth/size/body
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• at 20 weeks, males and females weights are decreased by 22% and 24%, respectively, relative to wild-type mice
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• on a high fat diet, mice are resistant to diet-induced obesity despite increased energy intake in male mice
• the relative mass gained per amount of food consumed by male mice is decreased to 40% of that in wild-type male mice and in female mice it is decreased to 70% of that in wild-type female mice
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• between 5 and 6 weeks, mice exhibit growth retardation
• between 14 and 15 weeks, mouse growth rate is dramatically diminished
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behavior/neurological
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• despite being able to produce milk, females are unable to nurse
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endocrine/exocrine glands
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• females exhibit premature involution during late pregnancy
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integument
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• females exhibit premature involution during late pregnancy
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