Analysis Tools
mortality/aging
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• during 7 months on a high fat diet, 39% of female mice die (the earliest at 13 weeks, 2 at 14 weeks, 1 each at 15, 19, 20, 21 and 27 weeks, and the last at 30 weeks)
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• 21% (12 of 56) female mice die on a regular diet
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adipose tissue
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• after 7 months on a high fat diet, the amount of white adipose tissue to body weight in females is 1.5-fold greater than in wild-type mice
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• the average adipocyte cell size in female mice on a high fat diet (0.191 ug/cell) is smaller than in wild-type mice (0.215 ug/cell)
• fat cell density is increased 1.1-fold in female mice fed a high fat diet compared to wild-type mice due to hyperplasia
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homeostasis/metabolism
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• at the end of 7 months, insulin levels in female mice on a high fat diet are increased 2-fold compared to in wild-type mice
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• leptin levels are increased by 2.4-fold in female mice fed a high fat diet relative to wild-type mice
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growth/size/body
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• at 32 weeks on a high fat diet, female mice exhibit a 1.6-fold increase in mass relative to wild-type mice
• from 21 to 25 weeks, relative mass gained per food consumed by female mice is greater than in wild-type mice
• a second group of female fed a high fat diet exhibit a 1.3-fold increase in mass at 32 weeks while eating 1.3-fold more food than wild-type mice
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• at 21 weeks of age on a high fat diet, female weight gain is increased relative to that observed in wild-type mice
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cardiovascular system
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• female mice develop atherosclerotic lesions in the root of the aorta on a high fat diet
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behavior/neurological
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• at 20 and 21 weeks on a high fat diet, food intake is increased relative to that of wild-type mice
• at 32 weeks, female mice eat 1.3-fold more food than wild-type mice
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